109022-85-7Relevant academic research and scientific papers
Synthesis and biological evaluation of new epalrestat analogues as aldose reductase inhibitors (ARIs)
Reddy, Thatikonda Narendar,Ravinder, Mettu,Bagul, Pankaj,Ravikanti, Keerthi,Bagul, Chandrakant,Nanubolu, Jagadeesh Babu,Srinivas, Kolupula,Banerjee, Sanjay K.,Rao, Vaidya Jayathirtha
, p. 53 - 66 (2014)
Baylis-Hillman chemistry derived four series of new epalrestat analogues were synthesized. Three structural changes are introduced in these 39 new epalrestat analogues synthesized. All compounds were evaluated for their in vitro aldose reductase inhibitor
The Morita-Baylis-Hillman reaction in aqueous-organic solvent system
de Souza, Rodrigo O.M.A.,Pereira, Vera L.P.,Esteves, Pierre M.,Vasconcellos, Mario L.A. A.
, p. 5902 - 5905 (2008)
We have found that water and organic solvents mixed at different proportions can give good to excellent yields and short reaction times for the Morita-Baylis-Hillman reaction. The present Letter details our findings in the Morita-Baylis-Hillman reaction b
The first one-pot synthesis of Morita-Baylis-Hillman adducts starting directly from alcohols
Yadav, Lal Dhar Singh,Srivastava, Vishnu Prabhakar,Patel, Rajesh
, p. 1047 - 1050 (2010)
The first example of one-pot oxidative carbon-carbon bond formation via the Morita-Baylis-Hillman reaction using alcohols is reported. The protocol involves silica gel-DABCO catalyzed oxidation of alcohols to aldehydes with chloramine-T followed by their
Iodine-catalyzed thioallylation of indoles using Bunte salts prepared from Baylis-Hillman bromides
Gupta, Prince Kumar,Yadav, Arvind Kumar,Sharma, Anup Kumar,Singh, Krishna Nand
, p. 3484 - 3488 (2021)
Metal-free iodine-catalyzed regioselective thioallylation of indoles has been accomplished at room temperature using Bunte salts prepared from Baylis-Hillman bromides. The resulting multi-functional C3 thioallylated indoles exhibit ample structural divers
Synthesis of novel poly(ethyleneglycol)-400 ionic liquid and its application in morita-baylis-hillman reaction
Zhao, San-Hu,Zhang, Qian-Jun,Duan, Xin-E,Feng, Li-Heng
, p. 3289 - 3297 (2011)
Novel Poly(ethyleneglycol)-400 ionic liquid containing imidazolium cations have been synthesized by the atom-efficient reaction of 1,2-dimethylimidazole with p-toluenesulfonate; the p-toluenesulfonate provides the anionic component of the resultant ionic
Baylis-Hillman reaction under solvent-free conditions - Remarkable rate acceleration and yield enhancement
Saikia, Monmi,Sarma, Jadab C.
, p. 1271 - 1276 (2010)
A simple and efficient method has been developed for remarkable rate acceleration and yield enhancement of the Baylis-Hillman reaction under solvent-free "neat conditions" and solvent-less isolation of products. Reaction of equimolar quantities of aldehyd
Ionic liquid-immobilized quinuclidine-catalyzed Morita-Baylis-Hillman reactions
Mi, Xueling,Luo, Sanzhong,Cheng, Jin-Pei
, p. 2338 - 2341 (2005)
(Chemical Equation Presented) The ionic liquid-bound quinuclidine catalyzed Baylis-Hillman reactions were investigated. The IL-supported catalyst showed equally good catalytic activity as compared with its nonimmobilized counterpart. The corresponding Bay
Microwave-Assisted 1,3-Dioxa-[3,3]-Sigmatropic Rearrangement of Substituted Allylic Carbamates: Application to the Synthesis of Novel 1,3-Oxazine-2,4-dione Derivatives
Bou Zeid, Samar,Eid, Samar,Najjar, Fadia,Macé, Aurélie,Rivilla, Ivan,Cossío, Fernando P.,Dorcet, Vincent,Roisnel, Thierry,Carreaux, Fran?ois
supporting information, (2021/11/22)
In a first instance, the effect of the microwave irradiation on the 1,3-Dioxa-[3,3]-sigmatropic rearrangement of aryl allylic carbamates was investigated. Under these new conditions, the reaction acceleration was clearly highlighted compared to convention
Substrate Profiling of the Cobalt Nitrile Hydratase from Rhodococcus rhodochrous ATCC BAA 870
Mashweu, Adelaide R.,Chhiba‐Govindjee, Varsha P.,Bode, Moira L.,Brady, Dean
, (2020/01/13)
The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in size from small (90 Da) to large (325 Da) were evaluated. Larger compounds included those with a biaryl axis, prepared by the Suzuki coupling reaction, Morita–Baylis–Hillman adducts, heteroatomlinked diarylpyridines prepared by Buchwald–Hartwig crosscoupling reactions and imidazo[1,2a]pyridines prepared by the Groebke–Blackburn–Bienaymé multicomponent reaction. The enzyme active site was moderately accommodating, accepting almost all of the small aromatic nitriles, the diarylpyridines and most of the biaryl compounds and Morita–Baylis–Hillman products but not the Groebke–Blackburn–Bienaymé products. Nitrile conversion was influenced by steric hindrance around the cyano group, the presence of electron donating groups (e.g., methoxy) on the aromatic ring, and the overall size of the compound.
N-Acylazole mediated stereoselective and regioselective synthesis of N-substituted azole acrylonitriles
Aydin, Osman,K?kten, ?ule,ünver, Hakan,?elik, ?lhami
, p. 1134 - 1148 (2019/09/10)
Regio- and stereoselective synthesis of N -substituted azole acrylonitriles has been achieved smoothly in N, N -dimethylformamide (DMF) in the presence of potassium carbonate (K 2 CO 3) as a base catalyst. N -Substituted azole acrylonitriles were obtained
