925212-41-5

Basic information

• Product Name: [5-((E)-6-[tert-butyldimethylsilyloxy]-1-hydroxy-2-hexenyl)-2,6,6-trimethyl-1-cyclohexenyl]methyl acetate
• Synonyms: [5-((E)-6-[tert-butyldimethylsilyloxy]-1-hydroxy-2-hexenyl)-2,6,6-trimethyl-1-cyclohexenyl]methyl acetate
• CAS NO: 925212-41-5
• Molecular Weight: 424.696
• Mol File: 925212-41-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [5-((E)-6-[tert-butyldimethylsilyloxy]-1-hydroxy-2-hexenyl)-2,6,6-trimethyl-1-cyclohexenyl]methyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: [5-((E)-6-[tert-butyldimethylsilyloxy]-1-hydroxy-2-hexenyl)-2,6,6-trimethyl-1-cyclohexenyl]methyl acetate(925212-41-5)
• EPA Substance Registry System: [5-((E)-6-[tert-butyldimethylsilyloxy]-1-hydroxy-2-hexenyl)-2,6,6-trimethyl-1-cyclohexenyl]methyl acetate(925212-41-5)

Safety Data

• Hazardous Substances Data: 925212-41-5(Hazardous Substances Data)

Upstream product

• 61362-77-4 5-[tert-butyldimethylsilyloxy]pent-1-yne 
• 144067-40-3 Acetic acid 5-formyl-2,6,6-trimethyl-cyclohex-1-enylmethyl ester 

Downstream Products

• 925212-44-8 (6E)-8-(3-acryloyl-2,2,4-trimethyl-3-cyclohexenyl)-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-one 
• 925415-14-1 (6E)-8-[3-(1-hydroxyallyl)-2,2,4-trimethyl-3-cyclohexenyl]-8-[(2-methoxyethoxy)methoxy]-1,6-octadien-3-ol 
• 925212-69-7 acetic acid 5-[6-hydroxy-1-(2-methoxy-ethoxymethoxy)-hex-2-enyl]-2,6,6-trimethyl-cyclohex-1-enylmethyl ester 
• 925212-42-6 6-(3-hydroxymethyl-2,2,4-trimethyl-cyclohex-3-enyl)-6-(2-methoxy-ethoxymethoxy)-hex-4-en-1-ol 
• 925212-68-6 acetic acid 5-[6-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-ethoxymethoxy)-hex-2-enyl]-2,6,6-trimethyl-cyclohex-1-enylmethyl ester 

Relevant articles and documents

Studies towards the synthesis of the bicyclic 3,8-secotaxane diterpenoid system using a ring closing metathesis strategy

Molecular modelling studies on the interations between taxanes and tubulins, developed by us, revealed that modified Taxuspines U and X could adopt a conformation similar to that of the bioactive conformation of paclitaxel and could be well accommodated within the proposed model. Accordingly, simplified Taxuspine U and X analogues have been rationally designed and their bicyclic 3,8-secotaxane diterpenoids intermediates have been synthesized through an approach that involves ring closing metathesis (RCM) as the key step for the macrocycle formation. Extensive studies on RCM have been performed using chemically diverse substrates, outlining the influence in the macrocyclization of the presence and position of functionalities, the molecular constraints and the importance of the site of ring closure.