925252-64-8Relevant academic research and scientific papers
Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents
Boone, Sarah,Das, Prasanta,Hamme, Ashton T.,Mitra, Dipanwita,Raucher, Drazen,Tandon, Ritesh,Turner, Lindsay
, p. 30223 - 30237 (2020/09/03)
Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The in vitro biological assays of synthesized compounds were probed for anti-viral activity
Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes
Jawalekar, Anup M.,Reubsaet, Erik,Rutjes, Floris P. J. T.,Van Delft, Floris L.
, p. 3198 - 3200 (2011/05/05)
Treatment of oximes with hypervalent iodine leads to substituted isoxazoles via rapid formation of nitrile oxides. Reaction with terminal alkynes led to a series of 3,5-disubstituted isoxazoles with complete regioselectivity and high yield, in a procedure
Oxonium ion-mediated synthesis of 4-substituted spiro-isoxazolines
McClendon, Eric,Omollo, Ann O.,Valente, Edward J.,Hamme II, Ashton T.
scheme or table, p. 533 - 535 (2009/04/14)
The stereoselective synthesis of 4-bromo-spiro-isoxazolines was achieved in one step through the bromination of various isoxazoles that contain a pendant alcohol or carboxylic acid functional group. Isoxazole bromination leads to a bromonium ion intermedi
Design and Synthesis of a Piperazinylalkylisoxazole Library for Subtype Selective Dopamine Receptor Ligands
Cha, Mi Young,Choi, Byung Chul,Kang, Kyung Ho,Pae, Ae Nim,Choi, Kung Il,Cho, Yong Seo,Koh, Hun Yeong,Lee, Hee-Yon,Jung, Daeyoung,Kong, Jae Yang
, p. 1327 - 1330 (2007/10/03)
A piperazinylbutylisoxazole library was designed, synthesized and screened for the binding affinities to dopamine D2, D3, and D4 receptors. Several ligands were identified to possess high binding affinity and selectivity for the D3 and D4 receptors over the D2 receptor. Compounds 6s and 6t showed Ki values of 2.6 nM and 3.9 nM for the D3 receptor with 46- and 50-fold selectivity over te D2 receptor, respectively.
