92532-12-2Relevant articles and documents
Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
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, (2008/06/13)
The invention relates to several aryloxy-alkane alcohols, for example 1-(3-(1-hydroxy-1-methylhexyl) phenoxy methyl)-2-methoxy-naphthalene, 2-(1-(3-(1-hydroxy-2,2-dimethylhexyl)phenoxy)ethyl naphthalene, 1-(3-6-phenoxy-1-hydroxyhexyl)phenoxy methyl)-4-methoxy naphthalene, 2-(3-(1-hydroxyhexyl) phenoxymethyl) naphthalene and 2-(3-(1-hydroxyhexyl)phenoxymethyl)-1,2,3,4-tetrahydro naphthalene, methods for their preparation and their use for treating inflammatory and allergic conditions in a mammal.
Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
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, (2008/06/13)
Compounds of the structure STR1 and pharmaceutically acceptable salts thereof, wherein R1 and R2 are independently hydrogen, alkyl, carboxy, alkylcarboxy, arylcarboxy, alkyl carbalkoxy, alkanoyl, formyl, nitrile, amino, amino alkyl, alkylamine, carboxamide, halo, trihalomethyl, hydroxy, alkoxy, aryloxy, nitro, sulfonyl, sulfonamide, thio, alkylthio, or R1 and R2 can be taken together to form a phenyl ring; B is C or N, in which N can be in any position of the ring; X is O, S, NR4, CH2 Z, CH=N, CH=CH, C C, CH2 ZCH2, C=O, C=CR or WC=O; Y is CHCH2, C=CH, C--CH2, CHCHR5, CHC(R5)2 or CC(R5)2 ; R3 is O, OH, OR4, SH, SR4, NH, HNR4 or N(R4)2 ; and M is an integer from 0 to 10; wherein Z is O, S or NR4 ; R4 is H, alkyl or aryl; W is O, S or NR4 ; and R5 is H, alkyl or fluoro have antiinflammatory and antiallergic activities.
