92536-05-5

Basic information

• Product Name: Benzonitrile, 3-(2-amino-1-hydroxyethyl)-
• Synonyms: Benzonitrile, 3-(2-amino-1-hydroxyethyl)-;3-(2-AMino-1-hydroxyethyl)benzonitrile
• CAS NO: 92536-05-5
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• Mol File: 92536-05-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzonitrile, 3-(2-amino-1-hydroxyethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 3-(2-amino-1-hydroxyethyl)-(92536-05-5)
• EPA Substance Registry System: Benzonitrile, 3-(2-amino-1-hydroxyethyl)-(92536-05-5)

Safety Data

• Hazardous Substances Data: 92536-05-5(Hazardous Substances Data)

Upstream product

• 1551723-92-2 C₉H₈BrNO 
• 550364-00-6 3-(1-hydroxy-2-nitroethyl)benzonitrile 
• 24964-64-5 3-Cyanobenzaldehyde 
• 50916-55-7 3-(2-bromoacetyl)benzonitrile 

Downstream Products

• 1184849-97-5 3-[2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-hydroxyethyl]benzonitrile 

Relevant articles and documents

1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase

A series of 1-aryl-2-(((6-aryl)pyrimidin-4-yl)amino)ethanols have been found to be competitive inhibitors of fatty acid amide hydrolase (FAAH). One member of this class, JNJ-40413269, was found to have excellent pharmacokinetic properties, demonstrated robust central target engagement, and was efficacious in a rat model of neuropathic pain.

Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route

This paper reports the synthesis and biological activity of a novel series of aryl-morpholine dopamine receptor agonists. Several compounds show high levels of functional selectivity for the D3 over the D2 dopamine receptor. Compound 26 has >1000-fold functional selectivity and has been successfully progressed in vivo using an intranasal delivery route.