92537-63-8Relevant academic research and scientific papers
Synthesis of pyrimidine, thiazolopyrimidine, pyrimidotriazine and triazolopyrimidine derivatives and their biological evaluation
Attaby, Fawzy A.,Eldin, Sanaa M.
, p. 788 - 798 (2007/10/03)
Pyrimidin-4-one-2-thione (3) was synthesized via the reaction of thiourea (1) with ethyl henzoylacetate (2) and was taken as a starting material for the present study via its reactions with the halogen-containing reagents 6a-d and 10a-c to give the corresponding thiazolopyrimidines 8, 9 and 12a-c. The 2-hydrazino derivatives 5 were synthesized either via the reaction of 3 or 4 with hydrazine hydrate. Compound 5 reacted with 6a-c and 10a-c to give the corresponding pyrimidotriazines 17a-c and 19 respectively. Also, compound 5 reacted with the active methylene-containing reagents 13 and 2a,b to give the corresponding 2-pyrazolopyrimidines 15 and 22a,b respectively. On the other hand, the triazolopyrimidines 21a,b and 30a,b were also obtained via the reaction of 5 with each of formic acid, acetic anhydride, ethyl chloroformate and carbon disulfide respectively. Some of the newly synthesized heterocyclic derivatives were tested for their biological activity.
Synthesis of New Condensed Pyrimidine Systems: Reactions of Heterocyclic Amines with Acetylenic Esters
Sahu, J. K.,Dehuri, S. N.,Naik, S.,Nayak, A.
, p. 117 - 120 (2007/10/02)
Several hitherto unreported 1,3,4-oxa/thiadiazolopyrimidin-7-ones (1 and 2) and thiazolopyrimidin-7-ones (3) have been synthesised by the reaction of 2-amino-1,3,4-oxa/thiadiazoles and 2-amino-4-arylthiazoles respectively with ethyl phenylpropiolate.The reaction of these amines with diethyl acetylenedicarboxylate furnishes the 7-oxo-5-carbethoxy derivatives (8-10).A similar reaction of 2-aminobenzothiazole with diethyl acetylenedicarboxylate affords 4-carbethoxypyrimidobenzothiazol-2(H)-one (7).To assign the structures of the 7-oxo derivatives the isomeric 5-oxo-7-carbethoxy derivatives (14) have also been synthesised by an unambiguous route.
