92539-55-4Relevant academic research and scientific papers
Rotationally Restricted Mimics of Rigid Molecules: Nonspirocyclic Hydantion Aldose Reductase Inhibitors
Rizzi, James P.,Schnur, Rodney C.,Hutson, Nancy J.,Kraus, Kenneth G.,Kelbaugh, Paul R.
, p. 1208 - 1213 (2007/10/02)
Sorbinil (1), a spirocyclic hydantoin, is a potent inhibitor of the enzyme aldose reductase.Simulation of the rigid spirocyclic ring orientation found in sorbinil was achieved with nonspirocyclic 5-hydantoins and 5-5'-
Treating diabetic complications with 5-(substituted phenyl)hydantoins
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, (2008/06/13)
A series of 5-(substituted phenyl)hydantoins and pharmaceutically acceptable salts thereof are aldose reductase inhibitors useful as agents for treatment of chronic diabetic complications; intermediates therefore; and processes for preparation of said com
