92540-07-3

Basic information

• Product Name: Butanenitrile, 3-oxo-2-[(3,4,5-trimethoxyphenyl)methylene]-, (Z)-
• CAS NO: 92540-07-3
• Molecular Formula: C14H15NO4
• Molecular Weight: 261.277
• Mol File: 92540-07-3.mol

Chemical Properties

• CAS DataBase Reference: Butanenitrile, 3-oxo-2-[(3,4,5-trimethoxyphenyl)methylene]-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanenitrile, 3-oxo-2-[(3,4,5-trimethoxyphenyl)methylene]-, (Z)-(92540-07-3)
• EPA Substance Registry System: Butanenitrile, 3-oxo-2-[(3,4,5-trimethoxyphenyl)methylene]-, (Z)-(92540-07-3)

Safety Data

• Hazardous Substances Data: 92540-07-3(Hazardous Substances Data)

Upstream product

• 5765-44-6 5-methylisoxazole 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 92540-10-8 2-Acetyl-3-(3,4,5-trimethoxyphenyl)-3-(2,4,6-triaminopyrimidin-5-yl)-propionitril 

Relevant articles and documents

Syntheses of 5-aryl-5,8-dihydropyrido[2,3-d]pyrimidine-2,4-diamines

2,4,6-Triaminopyrimidine is reacted with 3,4,5-trimethoxybenzylidene-1,3-dicarbonyl compounds to yield Michael adducts which are cyclised in acidic medium to the 5,8-dihydropyrido[2,3-d]diamines. The title compounds posses a rigid trimethoprim structure and are of interest as potential inhibitors of dihydrofolate reductase (DHFR).