Archiv der Pharmazie p. 709 - 713 (1984)
Update date:2022-08-04
Topics:
Troschutz
2,4,6-Triaminopyrimidine is reacted with 3,4,5-trimethoxybenzylidene-1,3-dicarbonyl compounds to yield Michael adducts which are cyclised in acidic medium to the 5,8-dihydropyrido[2,3-d]diamines. The title compounds posses a rigid trimethoprim structure and are of interest as potential inhibitors of dihydrofolate reductase (DHFR).
View MoreContact:+8613400661290
Address:No 908,Kangwan Rd, Liuyang Economic
MS( MAOSHENG )Chemical CO.,LTD
Contact:+86-519-82726678.82726378
Address:TAOXI INDUSTRY ZONE JINTAN
Nanjing Zelang Medical Technology Co. Ltd
Contact:86-25-83063290/13770714480
Address:Ganjiabian 108# 01 Unit,701-702 room,Yao Hua Street,Qixia District,Nanjing,Jiangsu,China
Suzhou Jingye Medicine & Chemical Co., Ltd
Contact:+86-512-66658588
Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Contact:+86-021-50792271
Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Doi:10.1016/j.tet.2006.11.062
(2007)Doi:10.1080/00397910600945894
(2006)Doi:10.1021/jm060878m
(2007)Doi:10.1021/ja067975p
(2007)Doi:10.1021/ja00026a028
(1991)Doi:10.1021/jm3012992
(2012)
