Archiv der Pharmazie p. 709 - 713 (1984)
Update date:2022-08-04
Topics:
Troschutz
2,4,6-Triaminopyrimidine is reacted with 3,4,5-trimethoxybenzylidene-1,3-dicarbonyl compounds to yield Michael adducts which are cyclised in acidic medium to the 5,8-dihydropyrido[2,3-d]diamines. The title compounds posses a rigid trimethoprim structure and are of interest as potential inhibitors of dihydrofolate reductase (DHFR).
View MoreNanjing Manhay Medical Technology Co.,Ltd
Contact:86-25-18061468449 13951924040
Address:Building5,Fuzhong Park,Xuanwu District
SHAANXI TOP PHARM CHEMICAL CO.LTD
Contact:+86-029-85733403
Address:No.108 ,west sector,south er huan,xi'an,china
Contact:+86-571-86491666
Address:SHI XIANG ROAD
Contact:+86-731-84427351
Address:154 JIANXIANG SOUTH ROAD
Angelisun(Chongqing) Pharmaceutical Co., LTD.
Contact:+86-23-68030926-816
Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
Doi:10.1016/j.tet.2006.11.062
(2007)Doi:10.1080/00397910600945894
(2006)Doi:10.1021/jm060878m
(2007)Doi:10.1021/ja067975p
(2007)Doi:10.1021/ja00026a028
(1991)Doi:10.1021/jm3012992
(2012)
