Archiv der Pharmazie p. 709 - 713 (1984)
Update date:2022-08-04
Topics:
Troschutz
2,4,6-Triaminopyrimidine is reacted with 3,4,5-trimethoxybenzylidene-1,3-dicarbonyl compounds to yield Michael adducts which are cyclised in acidic medium to the 5,8-dihydropyrido[2,3-d]diamines. The title compounds posses a rigid trimethoprim structure and are of interest as potential inhibitors of dihydrofolate reductase (DHFR).
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