925437-34-9

Basic information

• Product Name: [1,1'-Biphenyl]-3-carboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-
• CAS NO: 925437-34-9
• Molecular Formula: C29H27N5OS
• Molecular Weight: 493.632
• Mol File: 925437-34-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1,1'-Biphenyl]-3-carboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-3-carboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-(925437-34-9)
• EPA Substance Registry System: [1,1'-Biphenyl]-3-carboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-(925437-34-9)

Safety Data

• Hazardous Substances Data: 925437-34-9(Hazardous Substances Data)

Upstream product

• 925437-85-0 (6-(2-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)methanol 
• 925438-48-8 3-chloromethyl-6-(2-nitro-phenyl)-imidazo[2,1-b]thiazole 

Relevant articles and documents

The identification of the SIRT1 activator SRT2104 as a clinical candidate

We have identified SRT2104 (4) as the first direct synthetic SIRT1 activator clinical candidate. The compound was derived from the optimization of a previously described imidazo[1,2-b]thiazole scaffold. SRT2104 was selected as a development candidate based on a combination of biochemical activity and pharmacokinetic profile. The in vivo characteristics of SRT2104 were superior to those of analogues with similar activation profiles. The overall preclinical profile suggests that the compound has potential to provide therapeutic benefit in a clinical setting. 2013 Bentham Science Publishers.