925442-63-3

Basic information

• Product Name: 1-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-piperidin-2-one
• CAS NO: 925442-63-3
• Molecular Weight: 652.88
• Mol File: 925442-63-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-piperidin-2-one(925442-63-3)
• EPA Substance Registry System: 1-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-piperidin-2-one(925442-63-3)

Safety Data

• Hazardous Substances Data: 925442-63-3(Hazardous Substances Data)

Upstream product

• 39720-27-9 4-acetoxybenzyl chloride 
• 925439-99-2 1-(4-hydroxy-benzyl)-piperidin-2-one 
• 877142-02-4 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol 
• 675-20-7 piperidin-2-one 
• 224168-91-6 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propionic acid methyl ester 
• 925439-27-6 acetic acid 4-(2-oxo-piperidin-1-ylmethyl)-phenyl ester 
• 151070-87-0 4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine 

Relevant articles and documents

Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl] piperidine series of histamine H3 receptor antagonists

A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identified. Structural features responsible for the reduction of P450 activity, a typical liability of 4-substituted imidazoles, have been established.