925461-73-0

Upstream product

• 925462-31-3 carbonic acid allyl ester 2-oxo-2-phenyl-ethyl ester 
• 120820-40-8 1-(2-(((1,1-dimethylethyl)dimethylsilyl)oxy)phenyl)ethanone 
• 103548-04-5 2-(tert-butyldimethylsilanyloxy)-1-phenylethan-1-one 
• 2937-50-0 Allyl chloroformate 

Downstream Products

• 925461-82-1 (S)-(-)-2-(tert-butyldimethylsilyloxy)-2-phenylpent-4-enal 
• 1051945-72-2 2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-pent-4-en-1-one 
• 1051946-19-0 2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-pent-4-en-1-one 

Relevant academic research and scientific papers

Ligand controlled highly regio- and enantioselective synthesis of α-acyloxyketones by palladium-catalyzed allylic alkylation of 1,2-enediol carbonates

The palladium catalyzed decarboxylative asymmetric allylic alkylation of allyl 1,2-enediol carbonates 1 can decompose to either α-hydroxyketones 3 or α-hydroxyaldehydes 4. The product distribution is largely controlled by the ligand. Using Lnaph/sub

Enantioselective synthesis of α-tertiary hydroxyaldehydes by palladium-catalyzed asymmetric allylic alkylation of enolates

Chiral α-tertiary hydroxyaldehydes are very versatile building blocks in synthetic chemistry. Herein, we report the first examples of a catalytic asymmetric protocol for the synthesis of such compounds from readily available α-halo or α-hydroxy ketones or enol silyl ethers with excellent yields and enantioselectivity. Its synthetic utility is demonstrated in the short, efficient formal synthesis of (S)-oxybutynin. In this process, the chiral ligand controls the regioselectivity as well as the enantioselectivity. Copyright