92560-92-4

Upstream product

• 536-45-8 sodium anisate 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 637-69-4 4-Methoxystyrene 
• 93-55-0 1-phenyl-propan-1-one 
• 104-93-8 p-methylanizole 
• 93-54-9 1-Phenyl-1-propanol 
• 103-65-1 phenylpropane 
• 100-09-4 4-methoxybenzoic acid 
• 768-60-5 4-methoxyphenylacetylen 
• 637-50-3 1-phenylpropene 

Downstream Products

• 92560-96-8 4-(5-Methyl-4-phenyl-oxazol-2-yl)-phenol 
• 92560-98-0 2-Methyl-2-[4-(5-methyl-4-phenyl-oxazol-2-yl)-phenoxy]-propionic acid ethyl ester 
• 92561-04-1 2-Methyl-2-[4-(5-methyl-4-phenyl-oxazol-2-yl)-phenoxy]-propionic acid 
• 92560-97-9 [4-(5-Methyl-4-phenyl-oxazol-2-yl)-phenoxy]-acetic acid ethyl ester 
• 92561-03-0 [4-(5-Methyl-4-phenyl-oxazol-2-yl)-phenoxy]-acetic acid 

Relevant academic research and scientific papers

Copper-catalyzed α-C-H acyloxylation of carbonyl compounds with terminal alkynes

Herein, a copper/TBHP catalyst system for the α-C-H acyloxylation of carbonyl compounds is developed using terminal alkynes as the acyloxy source. A variety of carbonyl compounds and terminal alkynes are tolerated in this reaction. In addition, its possible mechanism is proposed.

Metal-free one-pot α-benzoxylation of benzylic alcohols with acids or aldehydes

A metal-free strategy has been developed for α-benzoxylation of benzylic alcohols with acids or aldehydes. The reaction proceeds via sequential oxidation and α-benzoxylation in one pot. Importantly, the reactions are performed in metal-free condition and utilize cheap aqueous TBHP as an oxidant, affording α-benzoxy ketones in moderate to good yields.

Method for preparing alpha-acyloxy ketone compound from terminal alkyne compounds

The invention provides a method for efficiently synthesizing an alpha-acyloxy ketone compound containing different substitute functional groups. According to the method, acetylacetone copper is taken as a reaction catalyst, t-butylhydroperoxide is taken as an antioxidant, ketone compounds and terminal alkyne compounds are taken as reaction substrates, and an organic solvent is added into a reaction system. The method has the advantages that the catalyst is cheap and easily available; reaction conditions are mild, safe and reliable; and the productivity of an obtained target product is relatively high. According to the method, the problem that a traditional alpha-acyloxylation reaction system is single is solved, and a novel acyloxylation reagent is provided; and the method has good industrial application prospects.

Method for preparing alpha-acyloxy ketone compound

The invention discloses a method for preparing an alpha-acyloxy ketone compound. According to the invention, simple and easily available alcohol and carboxylic acid are taken as the raw materials, under mediation of NBS(N-bromo-succinimide) and DBU(1,8-diazabicyclo(5.4.0)undec-7-alkene), the alpha-acyloxy ketone is prepared by a one-pot reaction. The method has the advantages of mild reaction condition, simple and easily available raw materials, wide substrate adaptation scope, no requirement of rigorous reaction conditions such as any metal catalyst, peroxy compounds, low or high temperature and water-free and oxygen-free conditions, metal pollution is avoided; and the method also has the advantages of stable technical condition, simple and safe operation, and easy purifying of the product.

Bu4NI-Catalyzed α-Oxyacylation of Carbonyl Compounds with Toluene Derivatives

A TBAI (tetrabutylammonium iodide)-catalyzed direct α-oxyacylation of carbonyl compounds from readily available toluene derivatives has been developed. The distinguished features of this metal-free protocol include the employment of simple starting material, a wide carbonyl compound scope, and mild reaction conditions.

Preparation of α-Acyloxy Ketones via Visible-Light-Driven Aerobic Oxo-Acyloxylation of Olefins with Carboxylic Acids

We developed a visible-light driven oxo-acyloxylation of aryl alkenes with carboxylic acids and molecular oxygen. A metal-free photoredox system, consisting of an acridinium photocatalyst, an organic base, and molecular sieve (MS) 4 ?, promotes chemoselective aerobic photooxidation of aryl alkenes. This approach may provide a green, practical, and metal-free protocol for a wide range of α-acyloxy ketones.

NBS/DBU mediated one-pot synthesis of α-acyloxyketones from benzylic secondary alcohols and carboxylic acids

A simple and efficient one-pot NBS/DBU-mediated method has been developed for the synthesis of α-acyloxyketones from various benzylic secondary alcohols and carboxylic acids. Through this methodology, a series of α-acyloxyketones could be obtained in good to excellent yields under mild conditions. Importantly, this new reaction avoids the direct usage of toxic metal catalysts or potentially dangerous peroxide oxidants.

Synthetic method of propiophenone compound

The invention provides a synthetic method of a propiophenone compound, belongs to the technical field of organic synthesis, and enables simplified reaction steps for synthesizing the propiophenone compound and reduction for reaction cost. The synthetic me

NBu4NI-catalyzed α-benzoxylation of ketones with terminal aryl alkenes

A metal-free protocol for the α-benzoxylation of ketones has been developed by using terminal aryl alkenes as an arylcarboxy surrogate. Moderate to good yields were attained for a variety of propiophenones and acetophenones by using tetra-n-butylammonium iodide (TBAI) as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant under ambient reaction conditions. An efficient synthesis for the α-benzoxylation of aryl ketones has been developed by using terminal aryl alkenes as the arylcarboxy surrogate. The products were obtained in moderate to good yields for a broad scope of substrates. Tetra-n-butylammonium iodide (TBAI) and tert-butyl hydroperoxide (TBHP) were employed as the catalyst and oxidant, respectively.

Potential Hypolipidemic Agents: Part III - Synthesis and Hypolipidemic Activity of 4-(4,5-Substituted oxazol-2-yl)phenoxyalkanoic Acid Derivatives

A number of 4-(4,5-substituted oxazol-2-yl)phenoxyalkanoic acid derivatives have been synthesised and evaluated for their hypolipidemic activity.Ethyl 4-(4-p-chlorphenyl-5-methyloxazol-2-yl)phenoxyacetate (3) exhibits significant hypocholesterolemic and h