92567-02-7

Basic information

• Product Name: 5-(4-Chloro-2-nitrophenyl)-2H-tetrazole
• Synonyms: 5-(4-Chloro-2-nitrophenyl)-2H-tetrazole
• CAS NO: 92567-02-7
• Molecular Formula: C7H4ClN5O2
• Molecular Weight: 225.59196
• Mol File: 92567-02-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 439.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.652±0.06 g/cm3(Predicted)
• PKA: 3.23±0.10(Predicted)
• CAS DataBase Reference: 5-(4-Chloro-2-nitrophenyl)-2H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Chloro-2-nitrophenyl)-2H-tetrazole(92567-02-7)
• EPA Substance Registry System: 5-(4-Chloro-2-nitrophenyl)-2H-tetrazole(92567-02-7)

Safety Data

• Hazardous Substances Data: 92567-02-7(Hazardous Substances Data)

Usage

General Description

5-(4-Chloro-2-nitrophenyl)-2H-tetrazole, also known as CL-88, is a chemical compound with the molecular formula C7H4ClN5O2. It is a yellow crystalline solid that is primarily used as a pharmaceutical intermediate in the synthesis of potential drug candidates. It is known for its high reactivity and explosive properties, making it a potent and versatile building block in organic synthesis. Its unique molecular structure, containing both a nitro group and a tetrazole ring, makes it a valuable component in the development of novel pharmaceuticals and agrochemicals. However, it should be handled with caution due to its potential explosive nature.

Upstream product

• 34662-32-3 4-chloro-2-nitrobenzonitrile 

Downstream Products

• 82212-14-4 5-(2-amino-4-chloro-5-sulphamoylphenyl)tetrazole 

Relevant articles and documents

Azosemide intermediate synthesizing method

The invention discloses an azosemide intermediate synthesizing method. The method comprises the steps of performing tetrazole reaction to prepare a compound A: warming and enabling 4-chlorin-2-nitro benzonitrile and sodium azide to react under action of a catalyst and extracting reaction liquid by water to obtain reaction liquid of the compound A; directly performing hydrogenation reaction to prepare a compound B; performing chlorosulfonation reaction to prepare a compound C: slowly dropping qualified compound B and chlorosulfonic acid into cold water after temperature reaction and center control qualification, extracting through an organic solvent, standing for layering and decompressing, evaporating and drying the solvent in an organic phase mode to obtain a compound crude product C; performing ammonolysis reaction to prepare a compound D. Compared with the prior art, raw materials of the method disclosed by the invention are easy to obtain and low in cost; the method is low in cost, convenient to operate, suitable for industrialization and little in generated three wastes; furthermore, comprehensive utilization of waste can meet national industrial policy.