925676-48-8Relevant academic research and scientific papers
Discovery of LAS101057: A potent, selective, and orally efficacious A 2B Adenosine Receptor Antagonist
Eastwood, Paul,Esteve, Cristina,Gonzalez, Jacob,Fonquerna, Silvia,Aiguade, Josep,Carranco, Ines,Domenech, Teresa,Aparici, Monica,Miralpeix, Montserrat,Alberti, Joan,Cordoba, Monica,Fernandez, Raquel,Pont, Merce,Godessart, Nuria,Prats, Neus,Loza, Maria Isabel,Cadavid, Maria Isabel,Nueda, Arsenio,Vidal, Bernat
, p. 213 - 218 (2011)
The structure-activity relationships for a series of pyrazine-based A 2B adenosine receptor antagonists are described. From this work, LAS101057 (17), a potent, selective, and orally efficacious A2B receptor antagonist, was identifie
PYRAZINE DERIVATIVES USEFUL AS ADENOSINE RECEPTOR ANTAGONISTS
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Page/Page column 118-119, (2008/06/13)
The present invention provides a compound of formula (I) wherein: A represents an optionally substituted monocyclic or polycyclic aryl or heteroaryl group B represents an optionally substituted monocyclic nitrogen-containing heteroaryl group ; and either a) R1 and R2 represent hydrogen or specified substituents, or b) R2, R1 and the -NH- group to which R1 is attached, form a moiety selected from the moiety of formulae (IIa) and (IIb): (IIa) These compounds are useful as antagonists of the A2B receptor, for instance in the treatment of asthma.
