925681-41-0

Usage

Uses

Used in Pharmaceutical Industry:
Akt Inhibitor X is used as a therapeutic agent for targeting the Akt signaling pathway, which is crucial in promoting cell survival and mediating resistance to apoptosis. Its ability to inhibit the phosphorylation of Akt and downstream targets makes it a promising candidate for the development of treatments aimed at combating various diseases, including cancer.
Used in Cancer Research:
Akt Inhibitor X is used as a research tool for studying the role of Akt in cancer cell growth, survival, and resistance to apoptosis. By inhibiting Akt phosphorylation, researchers can gain insights into the molecular mechanisms underlying cancer progression and identify potential therapeutic targets for the development of novel anticancer drugs.
Used in Drug Development:
Akt Inhibitor X is used as a lead compound in the development of new drugs targeting the Akt signaling pathway. Its cell-permeable, reversible, and selective properties make it an attractive starting point for the design and synthesis of more potent and specific Akt inhibitors with improved pharmacological properties.
Used in Apoptosis Studies:
Akt Inhibitor X is used as an inducer of apoptosis in cellular models to study the mechanisms of cell death and survival. By inhibiting Akt phosphorylation and its downstream targets, researchers can investigate the role of the Akt signaling pathway in the regulation of apoptosis and identify potential strategies to enhance the susceptibility of cancer cells to apoptosis-inducing agents.

references

[1]. janjetovic k, vucicevic l, misirkic m, et al. metformin reduces cisplatin-mediated apoptotic death of cancer cells through ampk-independent activation of akt. european journal of pharmacology, 2011, 651(1): 41-50.[2]. de abreu la, calixto c, waltero cf, et al. the conserved role of the akt/gsk3 axis in cell survival and glycogen metabolism in rhipicephalus (boophilus) microplus embryo tick cell line bme26. biochimica et biophysica acta (bba)-general subjects, 2013, 1830(3): 2574-2582.[3]. brunet a, bonni a, zigmond mj, et al. akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. cell, 1999, 96(6): 857-868.[4]. pulinilkunnil t, he h, kong d, et al. adrenergic regulation of amp-activated protein kinase in brown adipose tissue in vivo. journal of biological chemistry, 2011, 286(11): 8798-8809.