92573-02-9Relevant academic research and scientific papers
REFORMATSKY TYPE REACTION WITH NEW ALUMINIUM REAGENTS CONTAINING Al-Sn OR Al-Pb LINKAGE.
Matsubara,Tsuboniwa,Morizawa,Oshima,Nozaki
, p. 3242 - 3246 (1984)
Treatment of alpha -bromo carbonyl compounds with the reagent prepared from n-Bu//3SnLi and Et//2AlCl or from SnCl//2 and Et//2AlCl affords enolates which react with ketone or aldehyde to give beta -hydroxy carbonyl compounds in good to excellent yields. The reactions proceed similarly with the reagents which are generated from R//3PbLi (R equals Ph, n-Bu) and Et//2AlCl. Catalysis by the added Pd(PPh//3)//4 complex promotes the reduction effectively and improves the yields of the desired adducts. The regio- and stereoselectivities are disclosed.
Direct enantioselective synthesis of syn-1,3-diols by the reaction of aldehydes with enol silyl ethers in the presence of a chiral borane complex. Successive asymmetric aldol reaction and asymmetric reduction with one promoter
Kaneko, Yuichi,Matsuo, Takao,Kiyooka, Syun-Ichi
, p. 4107 - 4110 (2007/10/02)
A stoichiometric amount of the chiral borane 1 turned out to successively promote the asymmetric aldol reaction of aldehydes with enol silyl ethers and the following asymmetric reduction in one pot to afford syn-1,3-diols with high enantioselectivity.
REFORMATSY TYPE REACTION BY MEANS OF Bu3SnAlEt2 or Bu3PbAlEt2
Tsuboniwa, Noriyuki,Matsubara, Seijiro,Morizawa, Yoshitomi,Oshima, Koichiro,Nozaki, Hitosi
, p. 2569 - 2572 (2007/10/02)
Treatment of α-halo carbonyl compounds with title Sn-Al or Pb-Al reagents provides enolates which react with aldehydes or ketones to give β-hydroxy carbonyl compounds effectively.
