92574-75-9

Upstream product

• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 3587-60-8 Benzyloxymethyl chloride 

Downstream Products

• 148759-06-2 5-(N-benzyl-N-2-hydroxyethylamino)-2-benzyloxymethyl-4-chloro-3(2H)-pyridazinone 
• 148759-08-4 4-(N-benzyl-N-2-hydroxyethylamino)-2-benzyloxymethyl-5-chloro-3(2H)-pyridazinone 
• 938045-16-0 2-((benzyloxy)methyl)-4-chloro-5-methoxypyridazin-3(2H)-one 
• 1266244-99-8 C₁₃H₁₃ClN₂O₃ 
• 1266245-02-6 C₂₆H₂₅Cl₂F₃N₄O₄ 
• 1266245-01-5 C₁₃H₁₀ClF₃N₂O₅S 
• 1266245-00-4 C₁₂H₁₁ClN₂O₃ 
• 82137-51-7 5-Benzyloxymethyl-4-trimethylsilanyloxy-5H-imidazo[4,5-d]pyridazine 
• 82137-52-8 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-benzyloxymethylimidazo<4,5-d>pyridazin-4-one 
• 82151-43-7 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-benzyloxymethylimidazo<4,5-d>pyridazin-4-one 
• 92574-77-1 4-amino-5-nitro-2-benzyloxymethylpyridazin-3-one 
• 82137-50-6 5-<(benzyloxy)methyl>-1,5-dihydro-4H-imidazo<4,5-d>pyridazin-4-one 
• 92574-78-2 4,5-diamino-2-benzyloxymethyl-2H-pyridazine-3-one 
• 148759-09-5 4-(N-benzyl-N-2-chloroethylamino)-2-benzyloxymethyl-5-chloro-3(2H)-pyridazinone 

Relevant academic research and scientific papers

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF

A compound represented by Formula [1] (in the formula, Z1 represents N, CH, or the like; X1 represents NH or the like; R1 represents a heteroaryl group or the like; each of R2, R3, and R4 represents a hydrogen atom, a halogen atom, an alkoxy group, or the like; and R5 represents a heteroaryl group or the like) or salt thereof.

DERIVATIVES OF 2H PYRIDAZIN- 3 -ONES, THEIR PREPARATION AND THEIR USE AS SCD-1 INHIBITORS

The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: -R1 represents one or more groups such as: trif luoromethyl, halogen such as F, C1, -when n=m=1, W represents CH then Y represents oxygen, -U represents: ? either - (C=O) CH2NH- and is branched at position 4 of pyridazinone, then R2 represents H, ? or -(C=O)NH- and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, - R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enyzme inhibitors for the treatment of obesitz, tzpe-2 diabetes and lipid disorders.

Is samoquasine A indeed benzo[f]phthalazin-4(3H)-one? Unambiguous, straightforward synthesis of benzo[f]phthalazin-4(3H)-one and its regioisomer benzo[f]phthalazin-1(2H)-one

In search for the structural elucidation of samoquasine A, a natural product isolated from the seeds of Annona squamosa L., two benzo[f]phthalazinone isomers have been synthesized. The synthetic pathway followed to build up these skeletons is based on the combination of two Suzuki reactions on a pyridazinone precursor and a ring closure reaction via a condensation reaction. 1H NMR data of the synthesized compound allowed to establish that the structure of the natural product samoquasine A is not benzo[f]phthalazin-4(3H)-one, as previously suggested.

3(2H)-pyridazinone derivatives and process for the preparation thereof

Racemic or optically active new 3(2H)-pyridazinone derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said 3(2H)-pyridazinone derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new 3(2H)-pyridazinone derivatives according to the invention correspond to the general formula (I), STR1