92588-08-4Relevant articles and documents
THE SYNTHESIS OF NETILMICIN via COMPLEXING OF VICINAL AND NON-VICINAL AMINO-HYDROXYL GROUP PAIRS WITH DIVALENT TRANSITION-METAL CATIONS
Nagabhushan, Tattanahalli L.,Turner, William N.,Tsai, Hsinghan,Jaret, Robert S.,Schumacher, Doris,et al.
, p. 243 - 250 (1984)
Sisomicin was converted into 3,2',6'-tri-N-acetylsisomicin by acetylation of its 3'',4''-vicinal-cis and 1,2''-non-vicinal amino-hydroxyl group pair complex of copper(II) or cobalt(II) acetate.The tri-N-blocked derivative was reductively monoalkylated at the 1-position with acetaldehyde and sodium cyanoborohydride and then N-deprotected to give netilmicin.