92589-99-6Relevant academic research and scientific papers
Biosynthesis of LL-D253α in Phoma pigmentivora. Incorporation of 13C, 2H, and 18O Enriched Precursors
McIntyre, C. Rupert,Simpson, Thomas J.,Trimble, L. A.,Vederas, John C.
, p. 706 - 709 (2007/10/02)
The incorporation of 13C, 2H, and 18O labelled acetates and 18O2 gas into LL-D253α (1), a chromanone metabolite of Phoma pigmentivora, and analyses of the enriched metabolites by 13C and 2H n.m.r. and mass spectroscopy indicate its formation from two preformed polyketide chains; evidence for the mechanism of formation of the chromanone ring is presented, and a cyclopropyl intermediate is proposed to account for the unique randomisation of label observed in the hydroxyethyl side chain.
