925893-61-4Relevant academic research and scientific papers
Click chemistry based method for the preparation of maleinimide-type thiol-reactive labels
Link, Martin,Li, Xiaohua,Kleim, Jana,Wolfbeis, Otto S.
supporting information; experimental part, p. 6922 - 6927 (2011/02/23)
Maleinimides are widely used to label proteins and to derivatize thiols. The so-called click reaction was shown to allow the efficient introduction of the maleinimido group into azido-modified fluorophores (benzoxazines) by reacting them with an alkyne-mo
Surface-modified upconverting microparticles and nanoparticles for use in click chemistries
Mader, Heike S.,Link, Martin,Achatz, Daniela E.,Uhlmann, Katrin,Li, Xiaohua,Wolfbeis, Otto S.
experimental part, p. 5416 - 5424 (2010/09/11)
A method is described for modifying the surface of upconverting microparticles (UCμPs) and nanoparticles (UCNPs) such that they become amenable to click chemistry. Respective reagents are presented and used in both kinds of particles, either directly or in combination with tetraethoxysilane. The particles also were labeled by using the click reaction, a) with fluorophores to yield materials that have emission colors that depend on the wavelength of excitation ; b) with maleinimido groups (so to obtain labels for thiols), and c)with biotin (to make them useful for affinity studies based on the biotin-streptavidin system). We believe that both the UCμPs and UCNPs have the potential of being used in numerous areas including upconversion imaging, biolabeling, and derivatization, but also in encoding and security.
TRIAZOLE-CONTAINING RELEASABLE LINKERS, CONJUGATES THEREOF, AND METHODS OF PREPARATION
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Page/Page column 73-74, (2010/11/25)
This invention relates to compounds comprising one or more therapeutic and/or diagnostic moieties and one or more functional moieties linked together via one or more triazole-containing linkers and to their intermediates and methods of their preparation.
