925922-99-2

Upstream product

• 925922-98-1 N-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-4-(3-nitrophenyl)pyridin-2-yl}furan-2-carboxamide 

Downstream Products

• 925923-00-8 tert-butyl {3-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)-phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)-amino]-3-oxopropyl}carbamate 
• 1240298-41-2 tert-butyl {2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}carbamate 
• 925924-00-1 tert-butyl {2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}methylcarbamate 
• 1240298-42-3 tert-butyl (2S)-2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}pyrrolidine-1-carboxylate 
• 925923-71-3 tert-butyl (2R)-2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)carbamoyl]pyrrolidine-1-carboxylate 
• 925924-02-3 N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide 
• 925924-01-2 tert-butyl {3-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-3-oxopropyl}methylcarbamate 
• 925923-68-8 tert-butyl 2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}piperidine-1-carboxylate 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54

GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor has an essential role to modulate sex-hormones including GnRH. Though antagonists of GPR54 are expected to be novel drugs for sex-hormone dependent diseases such as prostate cancer or endometriosis, small molecule GPR54 antagonists have not been reported. We have synthesized a series of 2-acylamino-4,6-diphenylpyridines to identify potent GPR54 antagonists. Detailed structure-activity relationship studies led to compound 9l with an IC50 value of 3.7 nM in a GPR54 binding assay, and apparent antagonistic activity in a cellular functional assay.