N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide

Base Information

• Chemical Name: N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide
• CAS No.: 925922-99-2
• Molecular Formula: C₂₅H₁₉FN₄O₄
• Molecular Weight: 458.449
• Mol file: 925922-99-2.mol

Synonyms:N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide

Chemical Property of N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide

There total 1 articles about N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-4-(3-nitrophenyl)pyridin-2-yl}furan-2-carboxamide (925922-98-1) → N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide (925922-99-2)

Guidance literature:

With water; iron; ammonium chloride; In ethanol; for 0.333333h; Reflux;

DOI:10.1016/j.bmc.2010.04.036

Reference yield: 93.0%

N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide (925922-99-2) + chloroacetyl chloride (79-04-9) → N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide (925924-02-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 3h; Cooling with ice;

DOI:10.1016/j.bmc.2010.05.061

Reference yield: 82.0%

N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide (925922-99-2) + 2-(1-(tert-butoxycarbonyl)-2-piperidinyl)acetic acid (149518-50-3) → tert-butyl 2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}piperidine-1-carboxylate (925923-68-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 40h;

DOI:10.1016/j.bmc.2010.05.061

upstream raw materials:

N-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-4-(3-nitrophenyl)pyridin-2-yl}furan-2-carboxamide

Downstream raw materials:

tert-butyl {3-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)-phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)-amino]-3-oxopropyl}carbamate

tert-butyl {2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}carbamate

tert-butyl {2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}methylcarbamate

tert-butyl (2S)-2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}pyrrolidine-1-carboxylate