926013-40-3

Upstream product

• 926013-38-9 2,3,3a,4,5,6-hexahydro-3a-(3,4-dimethoxyphenyl)-3-methylthio-1-[(R)-1-(1-naphthyl)ethyl]indol-2-one 
• 1227473-71-3 C₃₀H₃₁NO₄S₂ 
• 5227-11-2 2-(3,4-dimethoxyphenyl)cyclohexanone 
• 926013-34-5 N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-α-(methylthio)-N-[(R)-1-(1-naphtyhl)ethyl]acetamide 
• 3886-70-2 (R)-1-(1-Naphthyl)ethylamine 

Downstream Products

• 943229-23-0 (3aS,7aS)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1-naphthyl)ethyl]octahydroindol-2-one 
• 943229-26-3 (3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindol-2-one 
• 943229-25-2 (3aS,7aS)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1-naphthyl)ethyl]octahydroindol-2-one 
• 943229-29-6 (3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole 

Relevant academic research and scientific papers

Stereoselective formal synthesis of (-)-mesembrane by intramolecular condensation of chiral amide and 1,3-cyclohexanedione moiety

A new stereoselective formal synthesis of (-)-mesembrane has been achieved by intramolecular condensation of chiral amide and 1,3-cyclohexanedione moiety. The precursor amide was readily prepared by condensation of the corresponding chiral amine and acid.

Stereoselective synthesis of cis and trans-fused 3a-aryloctahydroindoles using cyclization of N-vinylic α-(methylthio)acetamides: synthesis of (-)-mesembrane

Treatment of N-(2-arylcyclohex-1-en-1-yl)-α-(methylthio)acetamides with N-chlorosuccinimide (NCS) gave 3a-aryl-2,3,3a,4,5,6-hexahydro-3-(methylthio)indol-2-ones. Desulfurization of the cyclization products followed by a catalytic hydrogenation of the resu

Stereoselective synthesis of trans-3a-aryloctahydroindoles using cyclization of N-vinylic α-(methylthio)acetamides

Treatment of N-(2-arylcyclohex-l-enyl)-α-(methylthio)acetamide with NCS underwent cyclization to give 3a-arylhexahydroindol-2-one, which was stereoselectively converted into trans-3a-aryloctahydroindole.