92611-82-0Relevant articles and documents
Synthesis and anticoagulant, antipyretic and analgesic activities of some 4H-1-benzopyran-4-one derivatives
El-Diwani, Hoda I.,El-Sahrawi, Hend,Mahmoud, Sawsan S.,Miyase, Toshio
, p. 27 - 31 (2007/10/02)
New derivatives of 7-hydroxy-5,8-dimethoxy-2-methyl-4(H)-oxo-1-benzopyran-6-carboxaldehyde (2a) have been synthesized and tested for their anticoagulant, antipyretic and analgesic activities.Compounds 2a, b and 3a, c, d show significant anticoagulant effe
UV-A Photolysis of Khellin: Products and Reaction Mechanism
Caffieri, Sergio,Favretto, Donata
, p. 7059 - 7063 (2007/10/02)
Photolysis at 365 nm of khellin in various solvents was studied: the degradation rate strongly depends on solvent but not on polarity, since it is related to the singlet oxygen lifetime in each solvent.Eight products were isolated and characterized, some of which had previously been described as coming from chemical oxidation of khellin.Both facts support an oxic pathway for photolysis involving singlet oxygen and leading to unstable intermediates.These are rapidly decomposed by nucleophiles, suggesting possible interference - if they are also formed in vivo - with physiological processes during photochemotherapeutic treatment with khellin.
ORGANOPHOSPHORUS CHEMISTRY 25. THE UTILIZATION OF WITTIG REAGENTS IN LACTONE RING FORMATION. APPLICATION TO THE SYNTHESIS OF LINEAR FUROCOUMARINS AND PYRANOCOUMARINS
Atta, Sanaa M. S.,Hafez, Taghrid S.,Mahran, Mohamed R.
, p. 109 - 116 (2007/10/02)
A new and improved method for the preparation of linear furocoumarins (7a,b) and pyranocoumarins (10a,b) in high yields, is described.It depends upon reacting ylid-phosphoranes (5) with suitably substituted benzofuran-, (3) or the benzo-γ-pyrone-(4) moiety.Formation of the target compounds (7 and 10) is assumed to proceed via lactonization of cis alkyl α-hydroxycinnamate intermediates of types 6 and 9, respectively.The trans analogues 8 do not lactonize to 10 even upon heating in boiling toluene.The new compounds have been characterized by their spectroscopic data (IR, PMR, 13C NMR) and elementary analyses. Key words: Wittig-reaction; lactonization; preparation of linear furocoumarins, pyranocoumarins.
Oxymetalation of Khellin. Solvomercuration, Osmylation, and Palladium-Catalyzed Oxidation of the Furan Ring in Khellin. The Synthesis of Highly Oxygenated Chromones and 2-Substituted Furochromones
Gammill, Ronald B.,Nash, Sharon A.
, p. 3116 - 3123 (2007/10/02)
Oxidation of khellin with thallium(III) nitrate (TTN) in methanol results in the addition of two molecules of methanol across the 2,3-double bond in the furan ring.Oxidation of khellin with mercuric(II) nitrate (Hg(NO3)2) in aqueous THF followed by treatm
Catalytic Osmylation and Oxypalladation of Khellin. Two Useful Methods for Furan Ring Degradation. Replacement of the Furan Ring by an Isoxazole Ring.
Gammill, Ronald B.,Nash, Sharon A.
, p. 2953 - 2956 (2007/10/02)
Two oxidation reactions are described which result in the selective degradation of the furan ring in khellin.Conversion of these products to previously inaccessible analogues is described.