92617-58-8Relevant articles and documents
A prodrug compound, a prodrug-oligonucleotide synthesis reagents, and manufacture of oligonucleotide-prodrug compounds
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, (2017/02/24)
PROBLEM TO BE SOLVED: To provide a new prodrug compound where a protective group capable of leaving in a cell is added to an OH group or an SH group of a phosphate group included in a synthetic oligonucleotide which may be a phosphorothioate-type analog o
Drug delivery systems based on trimethyl lock lactonization: Poly(ethylene glycol) prodrugs of amino-containing compounds
Greenwald, Richard B.,Choe, Yun H.,Conover, Charles D.,Shum, Kwok,Wu, Dechun,Royzen, Maksim
, p. 475 - 487 (2007/10/03)
A novel methodology for the synthesis of poly(ethylene glycol) (PEG) prodrugs of amino-containing compounds has been developed which is based on the trimethyl lock lactonization reaction. These PEG-modified double prodrugs are water soluble, and by select
A MODEL FOR OLEFIN HYDRATION: INTRAMOLECULAR NUCLEOPHILIC ADDITION OF PHENOLATE OXYGEN TO THE UNACTIVATED DOUBLE BOND
Evans, Christopher M.,Kirby, Anthony J.
, p. 1259 - 1268 (2007/10/02)
Two series of phenol-olefins with strained ground states cyclise rapidly to ethers at high pH, where the phenol is fully ionised.The reaction involves intramolecular nucleophilic addition of phenolate oxygen to a monoalkylethylene.A primary carbanion is n