926226-12-2 Usage
General Description
1-[(3-Fluorophenyl)acetyl]piperazine hydrochloride is a chemical compound with the molecular formula C12H17ClFN2O. It is a piperazine derivative with a fluorophenylacetyl group attached to the piperazine ring. 1-[(3-Fluorophenyl)acetyl]piperazine hydrochloride is commonly used in pharmaceutical research as a potential candidate for the treatment of a variety of conditions, including anxiety, depression, and other neurological disorders. It is typically administered in its hydrochloride form for improved solubility and stability. The compound exhibits potential therapeutic effects due to its ability to modulate neurotransmitter pathways in the central nervous system, making it a subject of interest for further investigation and development in the field of psychopharmacology.
Check Digit Verification of cas no
The CAS Registry Mumber 926226-12-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,6,2,2 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 926226-12:
(8*9)+(7*2)+(6*6)+(5*2)+(4*2)+(3*6)+(2*1)+(1*2)=162
162 % 10 = 2
So 926226-12-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H15FN2O/c13-11-3-1-2-10(8-11)9-12(16)15-6-4-14-5-7-15/h1-3,8,14H,4-7,9H2
926226-12-2Relevant articles and documents
Synthesis, characterization, and anti-inflammatory activities of methyl salicylate derivatives bearing piperazine moiety
Li, Jingfen,Yin, Yong,Wang, Lisheng,Liang, Pengyun,Li, Menghua,Liu, Xu,Wu, Lichuan,Yang, Hua
, (2016)
In this study, a new series of 16 methyl salicylate derivatives bearing a piperazine moiety were synthesized and characterized. The in vivo anti-inflammatory activities of target compounds were investigated against xylol-induced ear edema and carrageenan-induced paw edema in mice. The results showed that all synthesized compounds exhibited potent anti-inflammatory activities. Especially, the anti-inflammatory activities of compounds M15 and M16 were higher than that of aspirin and even equal to that of indomethacin at the same dose. In addition, the in vitro cytotoxicity activities and anti-inflammatory activities of four target compounds were performed in RAW264.7 macrophages, and compound M16 was found to significantly inhibit the release of lipopolysaccharide (LPS)-induced interleukin (IL)-6 and tumor necrosis factor (TNF)-α in a dose-dependent manner. In addition, compound M16 was found to attenuate LPS induced cyclooxygenase (COX)-2 up-regulation. The current preliminary study may provide information for the development of new and safe anti-inflammatory agents.
