926245-76-3Relevant academic research and scientific papers
Facile synthesis of thiazoles via an intramolecular thia-Michael strategy
Sasmal, Pradip K.,Sridhar,Iqbal, Javed
, p. 8661 - 8665 (2006)
A mild and efficient method for the synthesis of substituted thiazoles is reported via one-pot N-desilylation, thioacylation/oxythioacylation/thiothioacylation followed by thia-Michael cycloisomerisation. This method has a general applicability to introdu
Pyridine Functionalized N-Heterocyclic Silane Complexes of Iridium and Rhodium-An Unexpected Change in Coordination
Kaiser, Felix,Reich, Robert M.,Rivard, Eric,Kühn, Fritz E.
, p. 136 - 144 (2018/01/17)
A new pyridine functionalized N-heterocyclic silane with ambident reactivity as a ligand has been synthesized and characterized by NMR spectroscopy (1H, 13C{1H}, 29Si), mass spectrometry, elemental analysis, and
Folding Patterns in a Family of Oligoamide Foldamers
Kortelainen, Minna,Suhonen, Aku,Hamza, Andrea,Pápai, Imre,Nauha, Elisa,Yliniemel?-Sipari, Sanna,Nissinen, Maija,Pihko, Petri M.
supporting information, p. 9493 - 9504 (2015/06/30)
A series of small, unsymmetrical pyridine-2,6-dicarboxylamide oligoamide foldamers with varying lengths and substituents at the end groups were synthetized to study their conformational properties and folding patterns. The @-type folding pattern resembled the oxyanion-hole motifs of enzymes, but several alternative folding patterns could also be characterized. Computational studies revealed several alternative conformers of nearly equal stability. These folding patterns differed from each other in their intramolecular hydrogen-bonding patterns and aryl-aryl interactions. In the solid state, the foldamers adopted either the globular @-type fold or the more extended S-type conformers, which were very similar to those foldamers obtained computationally. In some cases, the same foldamer molecule could even crystallize into two different folding patterns, thus confirming that the different folding patterns are very close in energy in spite of their completely different shapes. Finally, the best match for the observed NOE interactions in the liquid state was a conformation that matched the computationally characterized helix-type fold. Erase and refold: Like peptides, oligoamide foldamers fold into a number of different conformers that are very close in energy (see picture, stability energies in kcal mol-1 given in parentheses). By using a combination of computational, single-crystal X-ray diffraction, and NMR spectroscopic studies, these folding patterns have been identified and characterized for a family of seven different foldamers with varying substituents.
