92631-83-9

Basic information

• Product Name: 3-glucosyl-2,3′,4,4′,6-pentahydroxybenzophenone
• Synonyms: 3-glucosyl-2,3′,4,4′,6-pentahydroxybenzophenone
• CAS NO: 92631-83-9
• Molecular Weight: 424.361
• Mol File: 92631-83-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-glucosyl-2,3′,4,4′,6-pentahydroxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-glucosyl-2,3′,4,4′,6-pentahydroxybenzophenone(92631-83-9)
• EPA Substance Registry System: 3-glucosyl-2,3′,4,4′,6-pentahydroxybenzophenone(92631-83-9)

Safety Data

• Hazardous Substances Data: 92631-83-9(Hazardous Substances Data)

Upstream product

• 92665-82-2 maclurin 3-C-(6''-O-p-hydroxybenzoyl)-β-D-glucoside 
• 92631-85-1 maclurin 3-C-(2''-O-p-hydroxybenzoyl-6''-O-galloyl)-β-D-glucoside 
• 92631-84-0 maclurin 3-C-(2''-O-galloyl-6''-O-p-hydroxybenzoyl)-β-D-glucoside 
• 519-34-6 maclurin 
• 2492-87-7 4-nitrophenyl-β-D-glucoside 
• 133-89-1 UDP-glucose 

Downstream Products

• 4773-96-0 mangiferin 
• 24699-16-9 4-β-D-glucopyranosyl-1,3-6,7-tetrahydroxy-9H-xanthen-9-one 

Relevant articles and documents

Functional Characterization and Structural Basis of an Efficient Di-C-glycosyltransferase from Glycyrrhiza glabra

A highly efficient di-C-glycosyltransferase GgCGT was discovered from the medicinal plant Glycyrrhiza glabra. GgCGT catalyzes a two-step di-C-glycosylation of flopropione-containing substrates with conversion rates of >98%. To elucidate the catalytic mech

Probing the catalytic promiscuity of a regio- and stereospecific C-glycosyltransferase from Mangifera indica

The catalytic promiscuity of the novel benzophenone C-glycosyltransferase, MiCGT, which is involved in the biosynthesis of mangiferin from Mangifera indica, was explored. MiCGT exhibited a robust capability to regio- and stereospecific C-glycosylation of 35 structurally diverse druglike scaffolds and simple phenolics with UDP-glucose, and also formed O- and N-glycosides. Moreover, MiCGT was able to generate C-xylosides with UDP-xylose. The OGT-reversibility of MiCGT was also exploited to generate C-glucosides with simple sugar donor. Three aryl-C-glycosides exhibited potent SGLT2 inhibitory activities with IC50 values of 2.6×, 7.6×, and 7.6×10-7-M, respectively. These findings demonstrate for the first time the significant potential of an enzymatic approach to diversification through C-glycosidation of bioactive natural and unnatural products in drug discovery. C-glycodiversification: MiCGT, as the first benzophenone C-glycosyltransferase (CGT) from Mangifera indica, showed robust regio- and stereospecific C-glycosylation activity for 35 structurally diverse acceptors with UDP-glucose or xylose. The aryl-C-glycoside 1 exhibited potent antidiabetic activity toward SGLT2.