926634-53-9Relevant academic research and scientific papers
Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold
Marsilje, Thomas H.,Alper, Phil B.,Lu, Wenshuo,Mutnick, Daniel,Michellys, Pierre-Yves,He, Yun,Karanewsky, Donald S.,Chow, Donald,Gerken, Andrea,Lao, Jianmin,Kim, Min-Ju,Seidel, H. Martin,Tian, Shin-Shay
scheme or table, p. 5259 - 5262 (2009/05/07)
The lead optimization of a novel series of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor is reported. The chemical instability of the dihydro-benzo[a]carbazole lead 2 was successfully addressed in the design and eval
Compounds and Compositions as Tpo Mimetics
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Page/Page column 8, (2008/12/07)
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly disea
