92664-05-6

Basic information

• Product Name: PotassiuM 1-cyano-3-ethoxy-2,3-dioxopropan-1-ide
• Synonyms: PotassiuM 1-cyano-3-ethoxy-2,3-dioxopropan-1-ide;Ethyl3-cyano-2-oxopropanoatepotassiuMsalt;Propanoic acid, 3-cyano-2-oxo-, ethyl ester, ion(1-), potassium
• CAS NO: 92664-05-6
• Molecular Formula: C₆H₆NO₃*K
• Molecular Weight: 179.21504
• Mol File: 92664-05-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: PotassiuM 1-cyano-3-ethoxy-2,3-dioxopropan-1-ide(CAS DataBase Reference)
• NIST Chemistry Reference: PotassiuM 1-cyano-3-ethoxy-2,3-dioxopropan-1-ide(92664-05-6)
• EPA Substance Registry System: PotassiuM 1-cyano-3-ethoxy-2,3-dioxopropan-1-ide(92664-05-6)

Safety Data

• Hazardous Substances Data: 92664-05-6(Hazardous Substances Data)

Usage

General Description

Potassium 1-cyano-3-ethoxy-2,3-dioxopropan-1-ide, also known as potassium cyanoxalate, is a chemical compound with the molecular formula C5H5KO4. It is a white crystalline solid that is soluble in water and ethanol. PotassiuM 1-cyano-3-ethoxy-2,3-dioxopropan-1-ide is used in organic synthesis and as a reagent in chemical reactions. It is also used in the production of pharmaceuticals and agrochemicals. However, it is important to handle this compound with care as it can be toxic and may cause skin and eye irritation.

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 75-05-8 acetonitrile 

Downstream Products

• 1032334-56-7 5-amino-1H-pyrazole-3-carboxylic acid hydrochloride 
• 728896-69-3 N-methoxycarbonyl-3-aminopyrazole-5-carboxylic acid ethyl ester 
• 866837-96-9 5-amino-3-ethoxycarbonyl-1-phenylpyraole 

Relevant articles and documents

New geldanamycin derivatives with anti Hsp properties by mutasynthesis

Mutasynthetic supplementation of the AHBA blocked mutant strain of S. hygroscopicus, the geldanamycin producer, with 21 aromatic and heteroaromatic amino acids provided new nonquinoid geldanamycin derivatives. Large scale (5 L) fermentation provided four new derivatives in sufficient quantity for full structural characterisation. Among these, the first thiophene derivative of reblastatin showed strong antiproliferative activity towards several human cancer cell lines. Additionally, inhibitory effects on human heat shock protein Hsp90α and bacterial heat shock protein from H. pylori HpHtpG were observed, revealing strong displacement properties for labelled ATP and demonstrating that the ATP-binding site of Hsps is the target site for the new geldanamycin derivatives.

HETEROCYCLIC INHIBITORS OF MCT4

Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.

Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis

Taking into account the structure activity relationship information given by our previous studies, we designed and synthesized a small library of pyrazolylureas and imidazopyrazolecarboxamides fluorinated on urea moiety and differently decorated on pyrazo