926656-88-4Relevant academic research and scientific papers
Domino Aryne Annulation via a Nucleophilic-Ene Process
Xu, Hai,He, Jia,Shi, Jiarong,Tan, Liang,Qiu, Dachuan,Luo, Xiaohua,Li, Yang
supporting information, p. 3555 - 3559 (2018/03/21)
1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.
Protecting group free syntheses of (±)-columbianetin and (±)-angelmarin
Harris, Eric B.J.,Banwell, Martin G.,Willis, Anthony C.
supporting information; experimental part, p. 6887 - 6889 (2012/02/05)
A five-step and protecting group free synthesis of (±)-columbianetin from cyclohexane-1,3-dione is reported. The former compound was converted into its p-hydroxycinnamate derivative, (±)-angelmarin, using Coster's esterification procedure. Efforts to modi
New chemical access for pyran core embedded derivatives from bisalkenylated 1,3-diketones and 1,3-diketoesters via tandem C-dealkenylation and cyclization
Narender,Sarkar,Venkateswarlu,Kumar
experimental part, p. 6576 - 6579 (2011/02/24)
New chemical access has been developed for the synthesis of pyran core embedded derivatives from 1,3diketones and 1,3-diketoesters, in which the active methylene group of 1,3-diketone or 1,3-diketoester was alkenylated with three equivalents of alkenyl br
Direct palladium/carboxylic acid-catalyzed C-allylation of cyclic 1,3-diones with allylic alcohols in water
Gan, Kim-Hong,Jhong, Ciou-Jyu,Yang, Shyh-Chyun
, p. 1204 - 1212 (2008/09/17)
The direct activation of C-O bonds in allylic alcohols in water as a suspension medium by palladium complexes has been accelerated by carrying out the reactions in the presence of a carboxylic acid. The palladium-catalyzed allylation of cyclic 1,3-diones using allylic alcohols directly gave the corresponding C-allylated products in good yields.
α,α′-annulation of 2,6-prenyl-substituted cyclohexanone derivatives with malonyl chloride: Application to a short synthesis of (±)-clusianone. Formation and rearrangement of a biogenetic-like intermediate
Nuhant, Philippe,David, Marc,Pouplin, Thomas,Delpech, Bernard,Marazano, Christian
, p. 287 - 289 (2007/10/03)
(Chemical Equation Presented) Conditions were found for the successful Effenberger α,α′-annulation of 3,3-dimethyl-2,4,6-triprenyl cyclohexanone silyl enol ethers with malonyl chloride to give the corresponding bicyclo[3.3.1]nonane-trione in 35% yield, th
