58133-99-6

Usage

Chemical Class

2,2-Dimethyl-2,6,7,8-tetrahydro-chromen-5-one belongs to the class of chromenes, which are a group of organic compounds that include coumarin and its derivatives.

Derivative of Coumarin

It is a derivative of coumarin, which is a natural substance found in various plants.

Synthesis of Pharmaceuticals

2,2-Dimethyl-2,6,7,8-tetrahydro-chromen-5-one is used in the synthesis of pharmaceuticals, as a building block in organic chemistry.

Pharmacological Properties

It has been studied for its potential pharmacological properties, including its antioxidant, anti-inflammatory, and neuroprotective effects.

Therapeutic Applications

2,2-Dimethyl-2,6,7,8-tetrahydro-chromen-5-one has been the subject of research due to its potential therapeutic applications, particularly in the treatment of neurological disorders and cancer.

InChI:InChI=1/C11H14O2/c1-11(2)7-6-8-9(12)4-3-5-10(8)13-11/h6-7H,3-5H2,1-2H3

Upstream product

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Relevant academic research and scientific papers

A Modulator-Induced Defect-Formation Strategy to Hierarchically Porous Metal–Organic Frameworks with High Stability

The pore size enlargement and structural stability have been recognized as two crucial targets, which are rarely achieved together, in the development of metal–organic frameworks (MOFs). Herein, we have developed a versatile modulator-induced defect-formation strategy, in the presence of monocarboxylic acid as a modulator and an insufficient amount of organic ligand, successfully realizing the controllable synthesis of hierarchically porous MOFs (HP-MOFs) with high stability and tailorable pore characters. Remarkably, the integration of high stability and large mesoporous property enables these HP-MOFs to be important porous platforms for applications involving large molecules, especially in catalysis.

A functionalized graphene oxide and nano-zeolitic imidazolate framework composite as a highly active and reusable catalyst for [3 + 3] formal cycloaddition reactions

We report a facile coordination-induced growth approach to fabricate a SO3H-functionalized graphene oxide and nanosized zeolitic imidazolate framework composite (ZIF-8@SO3H-GO) under mild conditions. The interactions between the func

Preparation of MOF catalysts and simultaneously modulated metal nodes and ligands: Via a one-pot method for optimizing cycloaddition reactions

MOF catalysts were fabricated using a one-pot method that simultaneously adjusts the metal nodes and ligands. The pore environments, Lewis acids (LAs) and Br?nsted acids (BAs), were controlled when BA groups were used to modify the ligands and monoacids were used to adjust the metal nodes. The catalysts exhibited remarkable catalytic performance in cycloaddition reactions. This journal is

SUBSTITUTED BENZOTHIOPHENYL DERIVATIVES AS GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES

Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: wherein U1, U2, U3, R1, R2, Z, and W are defined herein.

Photothermal-enhanced catalysis in core-shell plasmonic hierarchical Cu7S4 microsphere@zeolitic imidazole framework-8

Conventional semiconductor photocatalysis based on band-edge absorption remains inefficient due to the limited harvesting of solar irradiation and the complicated surface/interface chemistry. Herein, novel photothermal-enhanced catalysis was achieved in a core-shell hierarchical Cu7S4 nano-heater@ZIF-8 heterostructures via near-infrared localized surface plasmon resonance. Our results demonstrated that both the high surface temperature of the photothermal Cu7S4 core and the close-adjacency of catalytic ZIF-8 shell contributed to the extremely enhanced catalytic activity. Under laser irradiation (1450 nm, 500 mW), the cyclocondensation reaction rate increased 4.5-5.4 fold compared to that of the process at room temperature, in which the 1.6-1.8 fold enhancement was due to the localized heating effect. The simulated sunlight experiments showed a photothermal activation efficiency (PTAE) of 0.07%, further indicating the validity of photothermal catalysis based on the plasmonic semiconductor nanomaterials. More generally, this approach provides a platform to improve reaction activity with efficient utilization of solar energy, which can be readily extended to other green-chemistry processes.

Lipase-catalyzed regioselective domino reaction for the synthesis of chromenone derivatives

An efficient synthesis of 2H-chromenones and 2-hydroxyl-2H-chromenones derivatives has been developed from 1,3-dicarbonyls and α,β-unsaturated aldehydes by a controllable regioselective domino cyclization reaction under catalysis of different lipases. 2H-Chromenones derivatives were synthesized by bovine pancreatic lipase (BPL) in acetonitrile, while lipase from Pseudomonas fluorescens (PFL) can catalyze the synthesis of the 2-hydroxyl-2H-chromenones derivatives in dichloromethane with moderate to high yields.

Microwave-assisted solvent and catalyst free synthesis of 2H-Pyrans

This paper describes a simple and efficient method involving domino Knovenegal/6π electrocyclization for the preparation of a variety of 2H-pyrans using microwave irradiation under solvent- and catalyst-free conditions. This method offers the advantages of a green approach, high yields, and short reaction times. Sixteen compounds (9a-p) were obtained in good to excellent yields using the procedure.

Environmentally benign, one-pot synthesis of pyrans by domino Knoevenagel/6π-electrocyclization in water and application to natural products

In water medium, environmentally benign, facile, and efficient synthesis of pyrans was achieved in good yields by the reactions of a variety of cyclic 1,3-dicarbonyls with several α,β-unsaturated aldehydes. The key strategy was a formal [3+3] cycloaddition by domino Knoevenagel/6π- electrocyclization. This methodology was applied to the synthesis of biologically interesting pyranocoumarin, pyranoquinolinone, and pyranonaphthoquinone derivatives along with selected natural and non-natural products. The Royal Society of Chemistry 2010.

Enantioselective wacker-type cyclization of 2-alkenyl-1,3-diketones promoted by Pd-SPRIX catalyst

(Equation Presented). An enantioselective intramolecular Wacker-type cyclization of 2-alkenyl-1,3-diketones catalyzed by a Pd(II)-SPRIX complex was developed. The reaction proceeded in a 6-endo-trig mode to give the desired chromene derivatives with moderate to good enantioselectivity. Isomerization of C-C double bonds via a π-allyl Pd intermediate was involved as the key step.

Metal-free Bronsted acid catalyzed formal [3 + 3] annulation. Straightforward synthesis of dihydro-2H-chromenones, pyranones, and tetrahydroquinolinones

(Chemical Equation Presented) Bronsted acids catalyze the addition of enolizable β-diketones, β-ketoesters, and vinylogous amides to α,β-unsaturated aldehydes to lead to substituted chromenones, pyranones, and tetrahydroquinolinones in good yields under mild reaction conditions via a formal [3 + 3] cycloaddition.