926658-98-2Relevant academic research and scientific papers
N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase
Bowers, Simeon,Probst, Gary D.,Truong, Anh P.,Hom, Roy K.,Konradi, Andrei W.,Sham, Hing L.,Garofalo, Albert W.,Wong, Karina,Goldbach, Erich,Quinn, Kevin P.,Sauer, John-Michael,Wallace, William,Nguyen, Lan,Hemphill, Susanna S.,Bova, Michael P.,Basi, Guriqbal S.
scheme or table, p. 6952 - 6956 (2010/06/16)
The structural modification of a series of [3.3.1] bicyclic sulfonamide based γ-secretase inhibitors is described. Appropriate substitution on the bicyclic scaffold provides a significant increase in the metabolic stability of the compounds resulting in an improved in vivo metabolic profile.
