92669-01-7

Basic information

• Product Name: PENTAETHYLENE GLYCOL MONOTETRADECYL ETHE R
• Synonyms: C14E5, Polyoxyethylene (5) myristyl ether, Tetradecyl pentaethylene glycol ether, Tetradecylpentaglycol
• CAS NO: 92669-01-7
• Molecular Formula: CH3(CH2)13(OCH2CH2)5OH
• Molecular Weight: 434.65
• Mol File: 92669-01-7.mol

Chemical Properties

• Melting Point: 32-33 °C
• Boiling Point: 511.3±40.0 °C(Predicted)
• Appearance: /
• Density: 0.957±0.06 g/cm3(Predicted)
• Refractive Index: 1.456
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: PENTAETHYLENE GLYCOL MONOTETRADECYL ETHE R(CAS DataBase Reference)
• NIST Chemistry Reference: PENTAETHYLENE GLYCOL MONOTETRADECYL ETHE R(92669-01-7)
• EPA Substance Registry System: PENTAETHYLENE GLYCOL MONOTETRADECYL ETHE R(92669-01-7)

Safety Data

• Hazardous Substances Data: 92669-01-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C24H50O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-26-17-19-28-21-23-30-24-22-29-20-18-27-16-14-25/h25H,2-24H2,1H3

Upstream product

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Relevant articles and documents

Nonionic Isatin Surfactants: Synthesis, Quantum Chemical Calculations, ADMET and Their Antimicrobial Activities

The most challenge task in the building up of surface-active molecules is maximizing their surface activity with good biological activity. A nonionic surfactant (N-isatin-EOm-Cn where m is 5, 7 and 9 ethylene glycol units and n is 8, 10 and 12) is achieved by first reacting isatin with chloroacetic acid and then with different types of ethoxylated (C8–C12) fatty alcohols that possess 5, 7 and 9 ethylene oxide units. The prepared surfactants were characterized by FTIR and 1H NMR to confirm the structure. The surface activity, biodegradability, antimicrobial, and antifungal activity of the surfactants were evaluated. In addition, quantum chemical calculations and computations of oral bioavailability were performed. The obtained data show that all the synthesized compounds had good surface activity, biodegradability and biological activity.

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.