926913-11-3

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 3-[bis(4-methoxyphenyl)phenylmethoxy]-4-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester, (3S,4S)-
• CAS NO: 926913-11-3
• Molecular Formula: C31H37NO8S
• Molecular Weight: 583.703
• Mol File: 926913-11-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 3-[bis(4-methoxyphenyl)phenylmethoxy]-4-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester, (3S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 3-[bis(4-methoxyphenyl)phenylmethoxy]-4-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester, (3S,4S)-(926913-11-3)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 3-[bis(4-methoxyphenyl)phenylmethoxy]-4-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester, (3S,4S)-(926913-11-3)

Safety Data

• Hazardous Substances Data: 926913-11-3(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 762-75-4 tert-butyl formate 
• 150986-62-2 S,S-3,4-dihydroxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 926913-07-7 (3S,4S)-1-N-tert-butyloxycarbonyl-3-(4,4'-dimethoxytrityloxy)-4-hydroxypyrrolidine 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 926913-24-8 (3S,4R)-4-(adenin-9-yl)-1-N-tert-butyloxycarbonyl-3-(4,4'-dimethoxytrityloxy)pyrrolidine 
• 1374429-77-2 (3R,4S)-tert-butyl 3-azido-4-(bis(4-methoxyphenyl)(phenyl)methoxy)pyrrolidine-1-carboxylate 
• 1412256-91-7 (3R,4S)-tert-butyl 3-(benzyloxycarbonylamino)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)pyrrolidine-1-carboxylate 
• 1193318-61-4 (3S,4R)-4-amino-1-N-Boc-3-dimethoxytrityloxypyrrolidine 
• 1174020-29-1 cis-3-amino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 926913-22-6 (3S,4R)-1-N-tert-butyloxycarbonyl-3-(4,4'-dimethoxytrityloxy)-4-(thymin-1-yl)-pyrrolidine 

Relevant articles and documents

Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring

Systematic structure-activity studies on a diverse family of nucleoside phosphonic acids has led to the development of potent antiviral drugs such as HPMPC (CidofovirTM), PMEA (AdefovirTM), and PMPA (TenofovirTM), which are used in the treatment of CMV-in

Synthesis of diastereomeric 3-hydroxy-4-pyrrolidinyl derivatives of nucleobases

The work deals with the synthesis of hydroxypyrrolidine analogs of nucleosides. Starting from the optically pure l- or d-tartaric acid, we improved the synthesis of enantiomeric trans-3,4-dihydroxypyrrolidines and elaborated a procedure for the synthesis of all possible diastereoisomers of 3-hydroxy-4-pyrrolidinyl derivatives of both purine and pyrimidine nucleobases. The prepared compounds were tested for cytostatic and antiviral properties but no significant activity was found.