927178-54-9

Basic information

• Product Name: (2-chloro-4-{4-[2-(2,4-dichlorophenoxy)ethylcarbamoyl]-5-phenylisoxazol-3-ylmethoxy}phenyl)acetic acid methyl ester
• CAS NO: 927178-54-9
• Molecular Weight: 589.859
• Mol File: 927178-54-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-chloro-4-{4-[2-(2,4-dichlorophenoxy)ethylcarbamoyl]-5-phenylisoxazol-3-ylmethoxy}phenyl)acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-4-{4-[2-(2,4-dichlorophenoxy)ethylcarbamoyl]-5-phenylisoxazol-3-ylmethoxy}phenyl)acetic acid methyl ester(927178-54-9)
• EPA Substance Registry System: (2-chloro-4-{4-[2-(2,4-dichlorophenoxy)ethylcarbamoyl]-5-phenylisoxazol-3-ylmethoxy}phenyl)acetic acid methyl ester(927178-54-9)

Safety Data

• Hazardous Substances Data: 927178-54-9(Hazardous Substances Data)

Upstream product

• 927178-36-7 [2-chloro-4-(4-chlorocarbonyl-5-phenylisoxazol-3-ylmethoxy)phenyl]acetic acid methyl ester 
• 1199-28-6 2-(2,4-dichlorophenoxy)ethylamine 
• 91182-77-3 3-methyl-5-phenylisoxazole-4-carbonyl chloride 
• 927178-35-6 3-(2-chloro-4-methoxycarbonylmethyl-phenoxymethyl)-5-phenylisoxazole-4-carboxylic acid tert-butyl ester 
• 927192-17-4 3-(2-chloro-4-methoxycarbonylmethyl-phenoxymethyl)-5-phenylisoxazole-4-carboxylic acid 
• 915194-74-0 3-bromomethyl-5-phenylisoxazole-4-carboxylic acid tert-butyl ester 
• 927178-21-0 3-methyl-5-phenylisoxazole-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists. Part 2

A series of PPARδ-selective agonists was investigated and optimized for a favorable in vivo pharmacokinetic profile. Isoxazole LCI765 (17d) was found to be a potent and selective PPARδ agonist with good in vivo PK properties in mouse (Cmax = 5.1 μM, t1/2 = 3.1 h). LCI765 regulated expression of genes involved in energy homeostasis in relevant tissues when dosed orally in C57BL6 mice. A co-crystal structure of compound LCI765 and the LBD of PPARδ is discussed.