92735-50-7Relevant academic research and scientific papers
(αMe)Hyv: Chemo-enzymatic synthesis, and preparation and preferred conformation of model depsipeptides
Peggion, Cristina,Barazza, Alessandra,Formaggio, Fernando,Crisma, Marco,Toniolo, Claudio,Villa, Marzia,Tomasini, Claudia,Mayrhofer, Herbert,Poechlauer, Peter,Kaptein, Bernard,Broxterman, Quirinus B.
, p. 644 - 651 (2002)
By a chemo-enzymatic approach we performed a large-scale, stereoselective synthesis of the Cα-methylated α-hydroxy acid L-(αMe)Hyv. We also prepared model depsipeptides based on this sterically demanding residue in combination with the α-amino
Two asymmetric syntheses of AMG 221, an inhibitor of 11β- hydroxysteroid dehydrogenase type 1
Caille, Seb,Cui, Sheng,Hwang, Tsang-Lin,Wang, Xiang,Faul, Margaret M.
experimental part, p. 3833 - 3842 (2009/11/30)
(Chemical Equation Presented) Two asymmetric syntheses of AMG 221 (2), an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) discovered in our laboratories, are reported. One of the syntheses utilizes chiral trimethylsilyl cyanohydrin 12 as s
Enzyme-catalyzed synthesis of (R)-ketone-cyanohydrins and their hydrolysis to (R)-α-hydroxy-α-methyl-carboxylic acids
Effenberger,Horsch,Weingart,Ziegler,Kuhner
, p. 2605 - 2608 (2007/10/02)
(R)-Ketone-cyanohydrins (R)-2 are obtained with high enantioselectivity from aliphatic ketones 1 and HCN in organic solvents using (R)-oxynitrilase ( EC 4.1.2.10) as catalyst. Acid catalyzed hydrolysis of the cyanohydrins (R)-2 affords the corresponding (R)-α-hydroxy-α-methyl-carboxylic acids (R)-3 without measurable racemization.
