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(6E)-6-[2-[6-[[(4E)-4-(6-oxo-1-cyclohexa-2,4-dienylidene)-6-phenyl-3H-pyrimidin-2-yl]amino]hexylamino]-6-phenyl-3H-pyrimidin-4-ylidene]cyclohexa-2,4-dien-1-one, also known as ONX 0914, is a selective inhibitor of the proteasome's immunoproteasome subunit LMP7. It is a complex organic compound with a unique molecular structure that has garnered interest for its potential therapeutic applications.
Used in Pharmaceutical Industry:
ONX 0914 is used as a therapeutic agent for the treatment of autoimmune and inflammatory diseases. Its application is based on its ability to modulate the immune response by targeting the proteasome, which plays a crucial role in the regulation of immune cell function.
Used in Oncology:
ONX 0914 is used as an anti-cancer agent for its potential to induce cell death in cancer cells. Its application is due to the role of the proteasome in regulating cell cycle progression and apoptosis, making it a promising target for cancer therapy.
Research is ongoing to further explore the therapeutic potential of ONX 0914 in various medical applications, including its use in combination therapies and drug delivery systems to enhance its efficacy and bioavailability.

92736-19-1

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92736-19-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 92736-19-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,7,3 and 6 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 92736-19:
(7*9)+(6*2)+(5*7)+(4*3)+(3*6)+(2*1)+(1*9)=151
151 % 10 = 1
So 92736-19-1 is a valid CAS Registry Number.

92736-19-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (6E)-6-[2-[6-[[(6E)-6-(6-oxocyclohexa-2,4-dien-1-ylidene)-4-phenyl-1H-pyrimidin-2-yl]amino]hexylamino]-4-phenyl-1H-pyrimidin-6-ylidene]cyclohexa-2,4-dien-1-one

1.2 Other means of identification

Product number -
Other names N(2),N'(2')-hexanediyl-1,6 bis(amino-2 o-hydroxyphenyl-4 phenyl-6 pyrimidine)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:92736-19-1 SDS

92736-19-1Downstream Products

92736-19-1Relevant academic research and scientific papers

Voies d'acces aux bisaminopyrimidines pontees par une chaine polymethylenique

Menichi, Gabriel,Hubert-Habart, Michel

, p. 209 - 213 (2007/10/02)

N(2),N'(2')-αω-Alkandiylbis(2-aminopyrimidines) are the sole products obtained by condensation of several polymethylene bisguanidines on ethyl ethoxymethylenemalonate, 3-methylchromone, flavone, acetylacetone, acetylaldehyde dimethylacetal and 3-acetyl-2-

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