927385-39-5

Upstream product

• 16088-62-3 (S)-Propylene oxide 
• 4440-01-1 lithium phenylacetylide 
• 536-74-3 phenylacetylene 
• 31552-04-2 (Z)-1-phenyl-3-penten-1-yne 
• 110411-10-4 (2S,3S)-2-Methyl-3-phenylethynyl-oxirane 

Downstream Products

• 927385-43-1 (S)-[4-(prop-2-ynyloxy)pent-1-ynyl]benzene 
• 84171-00-6 (E)-5-phenyl-4-penten-2-ol 
• 2344-71-0 (S)-(+)-5-phenyl-2-pentanol 
• 21441-45-2 (S,E)-3-benzylidene-5-methyldihydro-2(3H)-furanone 
• 1357017-35-6 (R)-2-bromo-5-phenylpentane 
• 927385-61-3 (S)-2-[N-(2-methylpropyl)-N-[4-(5-phenylpent-4-yn-2-yloxy)but-2-ynyl]amino]acetonitrile 
• 927385-54-4 (S)-3-[N-(2-methylpropyl)-[N-4-(5-phenylpent-4-yn-2-yloxy)but-2-ynyl]amino]propanenitrile 
• 927385-53-3 (S)-3-[N-(3-methylbutyl)-[N-4-(5-phenylpent-4-yn-2-yloxy)but-2-ynyl]amino]propanenitrile 
• 927385-52-2 (S)-3-[N-2-phenoxyethyl-[N-4-(5-phenylpent-4-yn-2-yloxy)but-2-ynyl]amino]propanenitrile 

Relevant academic research and scientific papers

Copper(I)-catalyzed boryl substitution of unactivated alkyl halides

Borylation of alkyl halides with diboron proceeded in the presence of a copper(I)/Xantphos catalyst and a stoichiometric amount of K(O-t-Bu) base. The boryl substitution proceeded with normal and secondary alkyl chlorides, bromides, and iodides, but alkyl sulfonates did not react. Menthyl halides afforded the corresponding borylation product with excellent diastereoselectivity, whereas (R)-2-bromo-5-phenylpentane gave a racemic product. Reaction with cyclopropylmethyl bromide resulted in ring-opening products, suggesting the reaction involves a radical pathway.

TETRAHYDROPYRANONAPHTHYRIDINES DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC TREATMENT THEREOF

This invention relates to tetrahydropyranonaphthyridines derivatives having formula (III) or IV: and analogues of the tetrahydropyranonaphthyridines derivatives. The invention also relates to pharmaceutical compositions comprising these compounds and meth

Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations

Microwave-promoted, cobalt-catalyzed intramolecular [2 + 2 + 2] cyclizations of dialkynylnitriles successfully gave 5,6,7,8-tetrahydro-1, 6naphthyridines. The efficient synthesis of these relatively simple, yet rarely addressed heterocycles enabled the pr

Enantioselective Epoxidation of Conjugated Dienes and Enynes. Trans-Epoxides from cis-Olefins

Asymmetric epoxidation of conjugated dienes and enynes catalyzed by (salen)Mn(II) coplex I takes place with high chemoselectivity to afford monoepoxides exclusively.Reactions of cis-enynes proceed with very high levels of asymmetric induction, with trans-alkynyl epoxides as the major products.