927385-39-5Relevant articles and documents
Copper(I)-catalyzed boryl substitution of unactivated alkyl halides
Ito, Hajime,Kubota, Koji
supporting information; experimental part, p. 890 - 893 (2012/05/05)
Borylation of alkyl halides with diboron proceeded in the presence of a copper(I)/Xantphos catalyst and a stoichiometric amount of K(O-t-Bu) base. The boryl substitution proceeded with normal and secondary alkyl chlorides, bromides, and iodides, but alkyl sulfonates did not react. Menthyl halides afforded the corresponding borylation product with excellent diastereoselectivity, whereas (R)-2-bromo-5-phenylpentane gave a racemic product. Reaction with cyclopropylmethyl bromide resulted in ring-opening products, suggesting the reaction involves a radical pathway.
Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations
Ya, Zhou,Porco Jr., John A.,Snyder, John K.
, p. 393 - 396 (2008/02/12)
Microwave-promoted, cobalt-catalyzed intramolecular [2 + 2 + 2] cyclizations of dialkynylnitriles successfully gave 5,6,7,8-tetrahydro-1, 6naphthyridines. The efficient synthesis of these relatively simple, yet rarely addressed heterocycles enabled the pr
