92739-79-2

Upstream product

• 92486-00-5 3-(2-benzyloxyacetyl)thiazolidine-2-thione 
• 104-53-0 3-phenyl-propionaldehyde 
• 92485-78-4 (E)-(2R,3R)-2-Benzyloxy-3-hydroxy-5-phenyl-1-(2-thioxo-thiazolidin-3-yl)-pent-4-en-1-one 
• 137238-71-2 (4R)-3-[2-(Phenylmethoxy)acetyl]-4-(phenylmethyl)oxazolidin-2-one 
• 862423-77-6 (4R)-3-[(2R,3R)-3-hydroxy-5-phenyl-2-(phenylmethoxy)pentanoyl]-4-benzyl-1,3-oxazolidin-2-one 
• 92739-78-1 (4R,5S)-5-Benzyloxy-2,2-dimethyl-4-((E)-styryl)-[1,3]dioxane 
• 292048-32-9 2-Benzyloxy-3-hydroxy-5-phenyl-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Complex aldol reactions for the construction of dense polyol stereoarrays: Synthesis of the C33-C36 region of aflastatin A

(Chemical Equation Presented) Facial selectivity in the addition of boron enolates of α-oxygenated ketones to anti-disposed α,β-bisalkoxy aldehydes is controlled by the aldehyde vicinal diol protecting group. Protection of the diol as an acetonide results in the exclusive formation of the anti-syn-anti stereoarray found in the C33-C36 region of aflastatin A.

VERSATILE RELATIVE AND ABSOLUTE STEREOCONTROL IN STANNOUS TRIFLATE MEDIATED ALDOL-TYPE REACTIONS OF 3-(2-BENZYLOXYACETYL)THIAZOLIDINE-2-THIONE

In the stannous triflate mediated aldol-type reactions of 3-(2-benzyloxyacetyl)thiazolidine-2-thione, stereochemical course of the reactions is dramatically altered by the addition of tetramethylethylenediamine as a ligand.High asymmetric induction is also achieved by the addition of chiral diamine derived from L-prolin.