927396-55-2

Upstream product

• 927396-54-1 (S)-4-[(4R)-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]-2-methylbutan-1-ol 
• 927396-58-5 (S)-4-[(4R)-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]-2-methylbutyraldehyde 
• 927396-43-8 (E)-(S)-7-[(4R)-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]-3,5-dimethyl-hept-3-en-2-one 

Downstream Products

• 927396-44-9 tert-butyl-{(E)-(1S,4S)-6-[(4R)-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]-1,2,4-trimethyl-hex-2-enyloxy}dimethylsilane 
• 115566-02-4 bistramide A 
• 927396-47-2 [(2E,9Z)-(1S,4S,7R)-10-[(2R,5S,6R)-6-(3-benzyloxypropyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-7-(4-methoxybenzyloxy)-1,2,4-trimethyl-deca-2,9-dienyloxy](tert-butyl)(dimethyl)silane 
• 927396-60-9 [(E)-(1S,4S,7S)-10-[(2S,5S,6R)-6-(3-benzyloxypropyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-7-(4-methoxy-benzyloxy)-1,2,4-trimethyl-dec-2-enyloxy](tert-butyl)(dimethyl)silane 
• 927396-48-3 {(E)-(1S,4S)-6-[(2S,6S,8R,9S)-8-(3-benzyloxy-propyl)-9-methyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,2,4-trimethyl-hex-2-enyloxy}-tert-butyl-dimethyl-silane 
• 927396-56-3 (E)-(3R,6S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-6,8-dimethyl-dec-7-en-1-ol 
• 927396-57-4 [(E)-(1S,4S,7R)-9-bromo-7-(4-methoxy-benzyloxy)-1,2,4-trimethyl-non-2-enyloxy]-tert-butyl-dimethyl-silane 

Relevant academic research and scientific papers

Synthesis of a 35-member stereoisomer library of bistramide A: Evaluation of effects on actin state, cell cycle and tumor cell growth

Synthesis and preliminary biological evaluation of a 35-member library of bistramide A stereoisomers are reported. All eight stereoisomers of the C1-C13 tetrahydropyran fragment of the molecule were prepared utilizing crotylsilane reagents 9 and 10 in our

Total synthesis of bistramide A

(Chemical Equation Presented) An asymmetric synthesis of the marine metabolite bistramide A is reported. The synthesis relies on the utility of three different organosilane reagents to construct all principle fragments and 8 of the 11 stereogenic centers of the natural product.