92741-82-7

Upstream product

• 20469-63-0 1-iodo-2,4-dimethoxybenzene 
• 105-53-3 diethyl malonate 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 92741-81-6 ethyl (2,4-dimethoxyphenyl)acetate 

Downstream Products

• 35618-98-5 3-(2,4-dimethoxy-phenyl)-4-hydroxy-8,9-dimethyl-7H-pyrano[2,3-e]indol-2-one 
• 92741-83-8 3-(2,4-dimethoxyphenyl)-4-hydroxy-7-methoxy-1H-quinolin-2-one 
• 59870-68-7 (±)-glabridin 
• 59870-68-7 glabridin 

Relevant academic research and scientific papers

Method for synthesizing glabridin

The invention relates to a method for synthesizing glabridin. According to the method, 2, 4-dimethoxy bromobenzene and diethyl malonate are used as starting raw materials, a key intermediate compound III is prepared through a cuprous iodide catalytic coupling reaction, a reduction reaction and a bromination reaction, methyl-protected glabridin is prepared through nucleophilic substitution and a Friedel-Crafts reaction, and glabridin is obtained after methyl is removed. According to the method for synthesizing glabridin, raw materials are cheap and easy to obtain, and the total yield is high.

Method for synthesizing optically pure glabridin

The invention relates to a method for synthesizing optically pure glabridin. According to the method, chiral carbon of optically pure glabridin is constructed through biological enzyme catalysis, optically pure glabridin is prepared in combination with an organic synthesis method, and the key steps are that a chiral intermediate compound III is generated by using a lipase catalysis compound II, and an important intermediate compound IV is obtained through a bromination reaction. According to the method for synthesizing optically pure glabridin, raw materials are cheap and easy to obtain, and the total yield is high.

Modular Synthesis of Diverse Natural Product-Like Macrocycles: Discovery of Hits with Antimycobacterial Activity

A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared. The approach was demonstrated in the synthesis of 17 diverse natural product-like macrocyclic scaffolds of varied (12–20-membered) ring size. The biological relevance of the chemical space explored was demonstrated through the discovery of a series of macrocycles with significant antimycobacterial activity.

Room-temperature copper-catalyzed α-arylation of malonates

An effective method in targeting α-aryl malonates is reported. In the presence of a catalytic amount of 2-picolinic acid and Cul, the coupling of aryl iodides with diethyl malonate proceeds smoothly even at room temperature. The high levels of functional group compatibility and exceptionally mild reaction conditions offer this an attractive protocol in accessing a variety of arylated malonates.

A general and mild copper-catalyzed arylation of diethyl malonate

Chemical equation presented A general method for the synthesis of α-aryl malonates is described. The coupling of an aryl iodide and diethyl malonate in the presence of Cs2CO3 and catalytic amounts of copper(I) iodide and 2-phenylphenol affords the α-aryl malonate in good to excellent yields. The mild reaction conditions and high levels of functional group compatibility make this an attractive synthetic alternative to previous methods.