927682-01-7

Upstream product

• 1165952-92-0 cyclohexa-1,4-diene 
• 256942-69-5 tert-butyl(2,2-dimethyl-3S,4S,7S-tetrahydro-1,3-benzodioxol-4-yl)dimethylsilane 
• 256942-83-3 (1S,2S,3S)-3-(trimethylsilyl)cyclohexane-4-ene-1,2-diol 
• 54380-53-9 cyclohexa-2,5-dien-1-yl(trimethyl)silane 
• 927681-97-8 (3S,4S,7S)-2,2-dimethyl-3,4,7-tetrahydro-1,3-benzodioxol-4-yl(trimethyl)silane 

Relevant academic research and scientific papers

Sequential desymmetrization-fluorination: Enantioselective synthesis of fluorinated cyclitols

An asymmetric synthesis of enantioenriched, highly functionalized fluorinated carbocycles has been developed based on an enantioselective Sharpless dihydroxylation of cyclohexa-dienylsilanes, combined with a diastereoselective electrophilic fluorodesilyla

Fluorination process

Compounds of formula (II), (IIIa) or (IIIb) (variables are described in the specification) are prepared by fluorination of β,γ-unsaturated alkyl silanes. These compounds are useful as building blocks in the pharmaceutical industry.