927690-08-2Relevant academic research and scientific papers
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: Exploring an innovative pharmacophore
Gemma, Sandra,Campiani, Giuseppe,Butini, Stefania,Kukreja, Gagan,Joshi, Bhupendra P.,Persico, Marco,Catalanotti, Bruno,Novellino, Ettore,Fattorusso, Ernesto,Nacci, Vito,Savini, Luisa,Taramelli, Donatella,Basilico, Nicoletta,Morace, Giulia,Yardley, Vanessa,Fattorusso, Caterina
, p. 595 - 598 (2007/10/03)
Identification of new molecular scaffolds structurally unrelated to known antimalarials may represent a valid strategy to overcome resistance of P. falciparum (Pf) to currently available drugs. We describe herein the investigation of a new polycyclic phar
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE
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Page/Page column 18, (2010/11/28)
Antimalarial agents having a novel pharmacophore of formula (I) are herein described. These polycyclic compounds are able to inhibit chloroquine-sensitive and chloroquine-resistant strains ofPlasmodium falciparum (Pf). Furthermore, the synthesis of these compounds involves few steps from commercial products with low cost of production.Λa présente invention concerne des agents antimalariaux comportant un nouveau pharmacophore de formule (I). Ces composés polycycliques sont susceptibles d''inhiber les souches sensibles à la chloroquine et résistantes à la chloroquine de Plasmodium falciparum (Pf). En outre, la synthèse de ces composés est peu onéreuse et implique peu d''étapes à partir des produits commerciaux.
