927802-68-4Relevant academic research and scientific papers
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors
Tessier, Pierre,Smil, David V.,Wahhab, Amal,Leit, Silvana,Rahil, Jubrail,Li, Zuomei,Deziel, Robert,Besterman, Jeffrey M.
, p. 5684 - 5688 (2009)
We have identified a series of diphenylmethylene hydroxamic acids as novel and selective HDAC class IIa inhibitors. The original hit, N-hydroxy-2,2-diphenylacetamide (6), has sub-micromolar class IIa HDAC inhibitory activity, while the rigidified oxygen a
