Bioorganic and Medicinal Chemistry Letters p. 5684 - 5688 (2009)
Update date:2022-08-04
Topics:
Tessier, Pierre
Smil, David V.
Wahhab, Amal
Leit, Silvana
Rahil, Jubrail
Li, Zuomei
Deziel, Robert
Besterman, Jeffrey M.
We have identified a series of diphenylmethylene hydroxamic acids as novel and selective HDAC class IIa inhibitors. The original hit, N-hydroxy-2,2-diphenylacetamide (6), has sub-micromolar class IIa HDAC inhibitory activity, while the rigidified oxygen a
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