927892-95-3

Upstream product

• 927892-94-2 4-[(4-fluorobenzyl)oxy]-1-[4-(hydroxymethyl)phenyl]pyridin-2(1H)-one 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 927892-97-5 tert-butyl (2S)-2-[({4-[4-[(4-fluorobenzyl)oxy]-2-oxopyridin-1(2H)-yl]benzyl}oxy)methyl]pyrrolidine-1-carboxylate 
• 927892-96-4 (R)-tert-butyl 3-({4-[4-[(4-fluorobenzyl)oxy]-2-oxopyridin-1(2H)-yl]benzyl}oxy)pyrrolidine-1-carboxylate 
• 1189572-63-1 C₂₃H₂₃FN₂O₂ 

Relevant academic research and scientific papers

Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists

Novel phenethylpyridone derivatives were identified as potent human melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. A search for surrogates for the 4-(2-aminoethoxy)phenyl moiety of 1 resulted in discovery of 2-[4-(aminomethyl)phenyl]ethyl substructure as in 6a. Successive optimization of the right-hand moiety led to the identification of a number of potent derivatives.

PHENYLPYRIDONE DERIVATIVE

A compound represented by the formula (I) is contained as an active ingredient: wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like, or R1 together with a nitrogen atom to which L, Z2 and R1 are attached may form an aliphatic nitrogenated heterocyclic group and R1 and R2 together with a nitrogen atom to which they are attached may form an aliphatic nitrogenated heterocyclic group; X represents a methine group or a nitrogen atom; Y represents -CH2-O-, -CH=CH- or the like; Z1 represents a single bond, a C1-4 alkylene group or the like; Z2 represents a single bond or a C1-4 alkylene group; L represents a methylene group, a C3-8 cycloalkylene group or the like; and Ar represents an aromatic carbocyclic group or the like. The compound is useful as a pharmaceutical for a central nerves system disease, a cardiovascular disease or a metabolic disease.