92795-72-7Relevant academic research and scientific papers
Method for preparation of alkyl phosphonyl compound from peroxide
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Paragraph 0025, (2019/10/01)
The invention discloses a method for preparation of an alkyl phosphonyl compound from peroxide. The invention adopts an acyl peroxide as the starting material, and the raw material is easily availableand has a great variety. The product obtained by the method provided by the invention has a great variety and wide uses. Some of the products can be reduced simply into important phosphorus ligands and key pharmaceutical intermediates. In addition, the method avoids the use of high toxicity phosphine reagent, has the characteristics of mild reaction conditions, simple operation, high target product yield, low pollution, simple reaction operation and post-treatment process, and is suitable for industrial production.
NiH-Catalyzed Reductive Relay Hydroalkylation: A Strategy for the Remote C(sp3)?H Alkylation of Alkenes
Zhou, Fang,Zhu, Jin,Zhang, Yao,Zhu, Shaolin
supporting information, p. 4058 - 4062 (2018/03/21)
The terminal-selective, remote C(sp3)?H alkylation of alkenes was achieved by a relay process combining NiH-catalyzed hydrometalation, chain walking, and alkylation. This method enables the construction of unfunctionalized C(sp3)?C(sp3) bonds under mild conditions from two simple feedstock chemicals, namely olefins and alkyl halides. The practical value of this transformation is further demonstrated by the large-scale and regioconvergent alkylation of isomeric mixtures of olefins at low catalyst loadings.
