928030-03-9

Upstream product

• 501-53-1 benzyl chloroformate 
• 51-35-4 4R-4-hydroxyproline 
• 578-66-5 8-amino quinoline 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 

Downstream Products

• 928030-10-8 (2S,4S)-benzyl 4-azido-2-(quinolin-8-ylcarbamoyl)pyrrolidine-1-carboxylate 
• 928030-04-0 (2S,4S)-benzyl 4-(4-(methoxycarbonyl)phenoxy)-2-(quinolin-8-ylcarbamoyl)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Stereoselective synthesis of diazabicyclic β-lactams through intramolecular amination of unactivated C(sp3)-H bonds of carboxamides by palladium catalysis

An efficient C(sp3)-H bond activation and intramolecular amination reaction via palladium catalysis at the β-position of carboxyamides to make β-lactams was described. The investigation of the substrate scope showed that the current reaction conditions favored activation of the β-methylene group. Short sequences were developed for preparation of various diazabicyclic β-lactam compounds with this method as the key step from chiral proline and piperidine derivatives.

BENZODIAZEPINE AND BENZOPIPERAZINE ANALOG INHIBITORS OF HISTONE DEACETYLASE

This invention relates to compounds for the inhibition of histone deacetylase More particularly, the invention provides for compounds of formula (I): wherein A, B, D, E, X1, X2, X3, X4 and n are as defined in the specification A method of inhibiting histone deacetylase in a cell, the method comprising contacting the cell with a compound of formula (I), in an amount sufficient to inhibit histone deacetylase, is also disclosed.